![]() | extracellular side |
cytoplasmic side |
CRUM3_HUMAN » Protein crumbs homolog 3 » | |
---|---|
Hydrophobic Thickness | 38.4 ± 1.6 Å |
Tilt Angle | 0 ± 0° |
ΔGtransfer | -58.7 kcal/mol |
ΔGfold | -29.1 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC |
Topology | Out |
TM Segments | 55-83 (54-86) |
Pathways | Cell-Cell communication (Reactome) Tight junction (KEGG) |
PDB | none |
OPM | none |
Complexes | none |
Interactions | none |
Domains | none |
UniProt annotation for CRUM3_HUMAN » Protein crumbs homolog 3 |
---|
FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. SUBUNIT: Interacts with MPP5, PARD6A and INADL. TISSUE SPECIFICITY: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate. DOMAIN: The PDZ-binding motif is involved in the interactions with PARD6A and MPP5. |
UniProt features for CRUM3_HUMAN » Protein crumbs homolog 3 |
---|
SIGNAL 1 26 Potential. CHAIN 27 120 Protein crumbs homolog 3. MOTIF 117 120 PDZ-binding. |
Amino Acid Sequence for CRUM3_HUMAN » Protein crumbs homolog 3 |
---|
MANPGLGLLL ALGLPFLLAR WGRAWGQIQT TSANENSTVL PSSTSSSSDG NLRPEAITAI IVVFSLLAAL LLAVGLALLV RKLREKRQTE GTYRPSSEEQ VGARVPPTPN LKLPPEERLI |