CRUM3_HUMAN » Protein crumbs homolog 3

CRUM3_HUMAN » Protein crumbs homolog 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CRUM3_HUMAN » Protein crumbs homolog 3 »
Hydrophobic Thickness 38.4 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -58.7 kcal/mol
ΔGfold -29.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 55-83 (54-86)
Pathways

Cell-Cell communication (Reactome)

Tight junction (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for CRUM3_HUMAN » Protein crumbs homolog 3
FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.

SUBUNIT: Interacts with MPP5, PARD6A and INADL.

TISSUE SPECIFICITY: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.

DOMAIN: The PDZ-binding motif is involved in the interactions with PARD6A and MPP5.

UniProt features for CRUM3_HUMAN » Protein crumbs homolog 3
SIGNAL 1 26 Potential.
CHAIN 27 120 Protein crumbs homolog 3.
MOTIF 117 120 PDZ-binding.
Amino Acid Sequence for CRUM3_HUMAN » Protein crumbs homolog 3
MANPGLGLLL ALGLPFLLAR WGRAWGQIQT TSANENSTVL PSSTSSSSDG NLRPEAITAI IVVFSLLAAL LLAVGLALLV RKLREKRQTE GTYRPSSEEQ VGARVPPTPN LKLPPEERLI