CRUM2_HUMAN » Protein crumbs homolog 2

CRUM2_HUMAN » Protein crumbs homolog 2
Magnify CRUM2_HUMAN » Protein crumbs homolog 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CRUM2_HUMAN » Protein crumbs homolog 2 » Crumbs-like protein 2;
Hydrophobic Thickness 36.4 ± 4.0 Å
Tilt Angle 0 ± 15°
ΔGtransfer -22.5 kcal/mol
ΔGfold -15.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1222-1246 (1222-1252)
Pathways

Hippo signaling pathway (KEGG)

PDB 2wo6 (C=4-9)
OPM none
Complexes none
Interactions none
Domains

AA: 112-142, PDBID: 1TOZ, Subunit A, Seq Identity:47%, EGF-like domain

AA: 150-180, PDBID: 3H5C, Subunit B, Seq Identity:54%, EGF-like domain

AA: 188-219, PDBID: 1TOZ, Subunit A, Seq Identity:52%, EGF-like domain

AA: 227-257, PDBID: 1TOZ, Subunit A, Seq Identity:52%, EGF-like domain

AA: 324-354, PDBID: 1EDM, Subunit B, Seq Identity:54%, EGF-like domain

AA: 362-392, PDBID: 4XBM, Subunit B, Seq Identity:51%, EGF-like domain

AA: 465-588, PDBID: 2R16, Subunit A, Seq Identity:19%, Laminin G domain

AA: 609-639, PDBID: 4XBM, Subunit B, Seq Identity:47%, EGF-like domain

AA: 811-841, PDBID: 1TPG, Subunit A, Seq Identity:51%, EGF-like domain

AA: 1060-1090, PDBID: 1TOZ, Subunit A, Seq Identity:48%, EGF-like domain

AA: 1103-1124, PDBID: 2YGQ, Subunit A, Seq Identity:41%, Human growth factor-like EGF

UniProt annotation for CRUM2_HUMAN » Protein crumbs homolog 2
FUNCTION: May play a role in polarized cells morphogenesis.

TISSUE SPECIFICITY: Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart.

DISEASE: Focal segmental glomerulosclerosis 9 (FSGS9) OMIM: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Note=The disease is caused by mutations affecting the gene represented in this entry.

DISEASE: Ventriculomegaly with cystic kidney disease (VMCKD) OMIM: A severe autosomal recessive developmental disorder manifesting in utero. It is characterized by cerebral ventriculomegaly, echogenic kidneys, microscopic renal tubular cysts and findings of congenital nephrosis. mutations affecting the gene represented in this entry.

UniProt features for CRUM2_HUMAN » Protein crumbs homolog 2
SIGNAL 1 28 Potential.
CHAIN 29 1285 Protein crumbs homolog 2.
DOMAIN 67 106 EGF-like 1.
DOMAIN 108 144 EGF-like 2; calcium-binding (Potential).
DOMAIN 146 182 EGF-like 3; calcium-binding (Potential).
DOMAIN 184 221 EGF-like 4; calcium-binding (Potential).
DOMAIN 223 259 EGF-like 5.
DOMAIN 261 318 EGF-like 6.
DOMAIN 320 356 EGF-like 7; calcium-binding (Potential).
DOMAIN 358 394 EGF-like 8; calcium-binding (Potential).
DOMAIN 396 436 EGF-like 9.
DOMAIN 431 603 Laminin G-like 1.
DOMAIN 605 641 EGF-like 10.
DOMAIN 647 805 Laminin G-like 2.
DOMAIN 807 843 EGF-like 11.
DOMAIN 871 1054 Laminin G-like 3.
DOMAIN 1056 1092 EGF-like 12.
DOMAIN 1094 1130 EGF-like 13.
DOMAIN 1134 1171 EGF-like 14.
DOMAIN 1173 1209 EGF-like 15.
DISULFID 71 82 By similarity.
DISULFID 76 94 By similarity.
DISULFID 96 105 By similarity.
DISULFID 112 123 By similarity.
DISULFID 117 132 By similarity.
DISULFID 134 143 By similarity.
DISULFID 150 161 By similarity.
DISULFID 155 170 By similarity.
DISULFID 172 181 By similarity.
DISULFID 188 199 By similarity.
DISULFID 193 208 By similarity.
DISULFID 210 220 By similarity.
DISULFID 227 238 By similarity.
DISULFID 232 247 By similarity.
DISULFID 249 258 By similarity.
DISULFID 265 276 By similarity.
DISULFID 270 306 By similarity.
DISULFID 308 317 By similarity.
DISULFID 324 335 By similarity.
DISULFID 329 344 By similarity.
DISULFID 346 355 By similarity.
DISULFID 362 373 By similarity.
DISULFID 367 382 By similarity.
DISULFID 384 393 By similarity.
DISULFID 400 411 By similarity.
DISULFID 405 424 By similarity.
DISULFID 426 435 By similarity.
DISULFID 579 603 By similarity.
DISULFID 609 620 By similarity.
DISULFID 614 629 By similarity.
DISULFID 631 640 By similarity.
DISULFID 766 805 By similarity.
DISULFID 811 822 By similarity.
DISULFID 816 831 By similarity.
DISULFID 833 842 By similarity.
DISULFID 1013 1054 By similarity.
DISULFID 1060 1071 By similarity.
DISULFID 1065 1080 By similarity.
DISULFID 1082 1091 By similarity.
DISULFID 1098 1108 By similarity.
DISULFID 1103 1118 By similarity.
DISULFID 1120 1129 By similarity.
DISULFID 1138 1150 By similarity.
DISULFID 1144 1159 By similarity.
DISULFID 1161 1170 By similarity.
DISULFID 1177 1188 By similarity.
DISULFID 1182 1197 By similarity.
DISULFID 1199 1208 By similarity.
Amino Acid Sequence for CRUM2_HUMAN » Protein crumbs homolog 2
MALARPGTPD PQALASVLLL LLWAPALSLL AGTVPSEPPS ACASDPCAPG TECQATESGG YTCGPMEPRG CATQPCHHGA LCVPQGPDPT GFRCYCVPGF QGPRCELDID ECASRPCHHG ATCRNLADRY ECHCPLGYAG VTCEMEVDEC ASAPCLHGGS CLDGVGSFRC VCAPGYGGTR CQLDLDECQS QPCAHGGTCH DLVNGFRCDC AGTGYEGTHC EREVLECASA PCEHNASCLE GLGSFRCLCW PGYSGELCEV DEDECASSPC QHGGRCLQRS DPALYGGVQA AFPGAFSFRH AAGFLCHCPP GFEGADCGVE VDECASRPCL NGGHCQDLPN GFQCHCPDGY AGPTCEEDVD ECLSDPCLHG GTCSDTVAGY ICRCPETWGG RDCSVQLTGC QGHTCPLAAT CIPIFESGVH SYVCHCPPGT HGPFCGQNTT FSVMAGSPIQ ASVPAGGPLG LALRFRTTLP AGTLATRNDT KESLELALVA ATLQATLWSY STTVLVLRLP DLALNDGHWH QVEVVLHLAT LELRLWHEGC PARLCVASGP VALASTASAT PLPAGISSAQ LGDATFAGCL QDVRVDGHLL LPEDLGENVL LGCERREQCR PLPCVHGGSC VDLWTHFRCD CARPHRGPTC ADEIPAATFG LGGAPSSASF LLQELPGPNL TVSFLLRTRE SAGLLLQFAN DSAAGLTVFL SEGRIRAEVP GSPAVVLPGR WDDGLRHLVM LSFGPDQLQD LGQHVHVGGR LLAADSQPWG GPFRGCLQDL RLDGCHLPFF PLPLDNSSQP SELGGRQSWN LTAGCVSEDM CSPDPCFNGG TCLVTWNDFH CTCPANFTGP TCAQQLWCPG QPCLPPATCE EVPDGFVCVA EATFREGPPA AFSGHNASSG RLLGGLSLAF RTRDSEAWLL RAAAGALEGV WLAVRNGSLA GGVRGGHGLP GAVLPIPGPR VADGAWHRVR LAMERPAATT SRWLLWLDGA ATPVALRGLA SDLGFLQGPG AVRILLAENF TGCLGRVALG GLPLPLARPR PGAAPGAREH FASWPGTPAP ILGCRGAPVC APSPCLHDGA CRDLFDAFAC ACGPGWEGPR CEAHVDPCHS APCARGRCHT HPDGRFECRC PPGFGGPRCR LPVPSKECSL NVTCLDGSPC EGGSPAANCS CLEGLAGQRC QVPTLPCEAN PCLNGGTCRA AGGVSECICN ARFSGQFCEV AKGLPLPLPF PLLEVAVPAA CACLLLLLLG LLSGILAARK RRQSEGTYSP SQQEVAGARL EMDSVLKVPP EERLI