CRTAM_HUMAN » Cytotoxic and regulatory T-cell molecule

CRTAM_HUMAN » Cytotoxic and regulatory T-cell molecule
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CRTAM_HUMAN » Cytotoxic and regulatory T-cell molecule » Class-I MHC-restricted T-cell-associated molecule;
Hydrophobic Thickness 36.8 ± 1.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -56.0 kcal/mol
ΔGfold -29.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 284-312 (281-315)
Pathways

Immune System (Reactome)

PDB 3rbg (A/B/C/D=18-117), 4h5s (A=18-117)
OPM none
Complexes

CRTAM:CADM1_HUMAN

CRTAM:CRTAM_HUMAN

Interactions

CADM1, Complex: CRTAM:CADM1, PDBID: 4H5S

CRTAM, Complex: Homodimer of cytotoxic and regulatory T-cell molecule, PDBID: 3RBG

Domains

AA: 21-115, PDBID: 3RBG, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 121-207, PDBID: 3BIK, Subunit A, Seq Identity:29%, CD80-like C2-set immunoglobulin domain

UniProt annotation for CRTAM_HUMAN » Cytotoxic and regulatory T-cell molecule
FUNCTION: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.

SUBUNIT: Interacts with CADM1.

TISSUE SPECIFICITY: In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues.

UniProt features for CRTAM_HUMAN » Cytotoxic and regulatory T-cell molecule
SIGNAL 1 17 Potential.
CHAIN 18 393 Cytotoxic and regulatory T-cell molecule.
DOMAIN 18 114 Ig-like V-type.
DOMAIN 118 210 Ig-like C2-type.
DISULFID 38 98
DISULFID 141 196 By similarity.
Amino Acid Sequence for CRTAM_HUMAN » Cytotoxic and regulatory T-cell molecule
MWWRVLSLLA WFPLQEASLT NHTETITVEE GQTLTLKCVT SLRKNSSLQW LTPSGFTIFL NEYPALKNSK YQLLHHSANQ LSITVPNVTL QDEGVYKCLH YSDSVSTKEV KVIVLATPFK PILEASVIRK QNGEEHVVLM CSTMRSKPPP QITWLLGNSM EVSGGTLHEF ETDGKKCNTT STLIIHTYGK NSTVDCIIRH RGLQGRKLVA PFRFEDLVTD EETASDALER NSLSSQDPQQ PTSTVSVTED SSTSEIDKEE KEQTTQDPDL TTEANPQYLG LARKKSGILL LTLVSFLIFI LFIIVQLFIM KLRKAHVIWK KENEVSEHTL ESYRSRSNNE ETSSEEKNGQ SSHPMRCMNY ITKLYSEAKT KRKENVQHSK LEEKHIQVPE SIV