CRR2_ARATH » Cysteine-rich repeat secretory protein 2

CRR2_ARATH » Cysteine-rich repeat secretory protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CRR2_ARATH » Cysteine-rich repeat secretory protein 2 » Cysteine-rich repeat protein HWI1;Plasmodesmata-located protein 5;PDLP5; Protein HOPW1-1-INDUCED 1;
Hydrophobic Thickness 34.8 ± 2.0 Å
Tilt Angle 0 ± 2°
ΔGtransfer -50.0 kcal/mol
ΔGfold -25.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 260-289 (258-292)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for CRR2_ARATH » Cysteine-rich repeat secretory protein 2
FUNCTION: Modulates cell-to-cell trafficking. Has a positive role in innate immunity. Negative regulator of plasmodesmata permeability triggered by salicylic acid during immune responses, through regulation of callose deposition. Delays the trafficking of Tobacco Mosaic Virus (TMV) movement protein (MP).

SUBUNIT: Interacts with Grapevine fanleaf virus (GFLV) 2B-MP.

TISSUE SPECIFICITY: Highly expressed in inflorescence nodes and rosette senescent leaves. Mostly expressed in cell wall junctions between leaf epidermal and mesophyl cells, and to a lesser extent at the cross walls between epidermal or cortex cells within the hypocotyl (at protein level). Low vascular expression in seedling and mature leaf, but high expression in senescing leaves (at protein level).

INDUCTION: By the Pseudomonas syringae pv. maculicola effector HopW1-1. By salicylic acid.

UniProt features for CRR2_ARATH » Cysteine-rich repeat secretory protein 2
SIGNAL 1 25
CHAIN 26 299 Cysteine-rich repeat secretory protein 2.
DOMAIN 29 135 Gnk2-homologous 1.
DOMAIN 137 237 Gnk2-homologous 2.
REGION 265 285 Necessary and sufficient for plasmodesmal targeting.
DISULFID 36 113
DISULFID 89 98
DISULFID 101 126
DISULFID 148 215
DISULFID 191 200
DISULFID 203 228
Amino Acid Sequence for CRR2_ARATH » Cysteine-rich repeat secretory protein 2
MIKTKTTSLL CFLLTAVILM NPSSSSPTDN YIYAVCSPAK FSPSSGYETN LNSLLSSFVT STAQTRYANF TVPTGKPEPT VTVYGIYQCR GDLDPTACST CVSSAVAQVG ALCSNSYSGF LQMENCLIRY DNKSFLGVQD KTLILNKCGQ PMEFNDQDAL TKASDVIGSL GTGDGSYRTG GNGNVQGVAQ CSGDLSTSQC QDCLSDAIGR LKSDCGMAQG GYVYLSKCYA RFSVGGSHAR QTPGPNFGHE GEKGNKDDNG VGKTLAIIIG IVTLIILLVV FLAFVGKCCR KLQDEKWCK