CRN_ARATH » Inactive leucine-rich repeat receptor-like protein kinase CORYNE

CRN_ARATH » Inactive leucine-rich repeat receptor-like protein kinase CORYNE
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CRN_ARATH » Inactive leucine-rich repeat receptor-like protein kinase CORYNE » Protein SUPPRESSOR OF OVEREXPRESSION OF LLP1 2;
Hydrophobic Thickness 34.4 ± 3.4 Å
Tilt Angle 2 ± 1°
ΔGtransfer -43.7 kcal/mol
ΔGfold -17.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 60-88 (53-88)
Pathways

Spliceosome (KEGG)

PDB none
OPM none
Complexes none
Interactions

CLV1, Complex: CLV1:CRN

CLV2, Complex: CRN:CLV2

P2C70, Complex: CRN:P2C70

Domains

AA: 119-396, PDBID: 3TL8, Subunit A, Seq Identity:30%, Protein kinase domain

UniProt annotation for CRN_ARATH » Inactive leucine-rich repeat receptor-like protein kinase CORYNE
FUNCTION: Involved in the perception of CLV3 peptide that acts as a mobile signal regulating meristems maintenance. Modulates root, shoot and flower apical meristems maintenance and floral organ development regulation, probably via CLAVATA (CLV)-like pathways involving at least CLV3 and CLE19.

SUBUNIT: Self-interacts. Parts of a tetrameric complex made of one CRN dimer and two CLV2 that can interact with CLV3 and CLV1 dimers. Interacts with CLV1 and CLV2.

TISSUE SPECIFICITY: Present in roots, stems, leaves, inflorescence, flowers and siliques. Mostly expressed in shoot tips and, to a lesser extent, in young organs and roots.

DEVELOPMENTAL STAGE: First observed in 16-cells stage embryo and surrounding region. From early heart to early torpedo stage, confined to the developing vasculature of the hypocotyl, cotyledons, and developing root. Faint expression in the emerging shoot apical meristem (SAM) at the torpedo stage. After germination, present in root, shoot and inflorescence meristems, as well as in young flower primordia and ovules. In roots, detected in the basal end of the root meristem, comprising the quiescent center, surrounding initials, and vascular precursors. Also present in the vasculature of primary and lateral roots, in the pericycle at sites of lateral root initiation, in lateral root meristems, and in the vasculature of the leaves. Accumulates in stamen and carpel primordia. Expressed in young provascular tissue of floral organs and stem tissue.

DOMAIN: The protein kinase domain is predicted to be catalytically inactive.

UniProt features for CRN_ARATH » Inactive leucine-rich repeat receptor-like protein kinase CORYNE
SIGNAL 1 33 Potential.
CHAIN 34 401 Inactive leucine-rich repeat receptor- like protein kinase CORYNE.
DOMAIN 118 401 Protein kinase.
Amino Acid Sequence for CRN_ARATH » Inactive leucine-rich repeat receptor-like protein kinase CORYNE
MKQRRRRNGC SSSNTISLLL LFFLVFFSRT STSTSCRRRT VKHLSTTSTS STPLESRITS KVIVISIVSG ILTGLVSALV LAFLVRSIVK FMKQTPILKG PVVFSPKITP KSLHAALSNG IQLLGSDLNG KYYKMVLDNG LVVAVKRLGS LEGVGSPESS SSKSVKRRLQ KELELLAGLR HRNLMSLRAY VRESDEFSLV YDYMPNGSLE DVMNKVRTKE VELGWEIRLR VAVGIVKGLQ YLHFSCETQI LHYNLKPTNV MLDSEFEPRL ADCGLAKIMP SSHTAVSCYS APESSQSNRY TDKSDIFSFG MILGVLLTGR DPTHPFCEES ASGGSLGQWL KHLQQSGEAR EALDKTILGE EVEEDEMLMA LRITIICLSD FPADRPSSDE LVHMLTQLHS F