CRLF2_HUMAN » Cytokine receptor-like factor 2

CRLF2_HUMAN » Cytokine receptor-like factor 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CRLF2_HUMAN » Cytokine receptor-like factor 2 » Cytokine receptor-like 2;IL-XR;Thymic stromal lymphopoietin protein receptor;TSLP receptor;
Hydrophobic Thickness 28.4 ± 2.0 Å
Tilt Angle 8 ± 5°
ΔGtransfer -37.0 kcal/mol
ΔGfold -23.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 231-255 (231-258)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB none
OPM none
Complexes

IL7RA:CRLF2:TSLP_MOUSE

Interactions

IL7RA, Complex: IL7RA:CRLF2:TSLP, PDBID: 4NN5, PubMed

Domains none
UniProt annotation for CRLF2_HUMAN » Cytokine receptor-like factor 2
FUNCTION: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.

SUBUNIT: Heterodimer of CRLF2 and IL7R.

TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

INDUCTION: Up-regulated in activated peripheral monocytes and THP- 1 cells.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is important for association with JAKs.

MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

UniProt features for CRLF2_HUMAN » Cytokine receptor-like factor 2
SIGNAL 1 22 Potential.
CHAIN 23 371 Cytokine receptor-like factor 2.
DOMAIN 119 207 Fibronectin type-III.
MOTIF 200 204 WSXWS motif.
MOTIF 261 269 Box 1 motif.
DISULFID 71 84 By similarity.
Amino Acid Sequence for CRLF2_HUMAN » Cytokine receptor-like factor 2
MGRLVLLWGA AVFLLGGWMA LGQGGAAEGV QIQIIYFNLE TVQVTWNASK YSRTNLTFHY RFNGDEAYDQ CTNYLLQEGH TSGCLLDAEQ RDDILYFSIR NGTHPVFTAS RWMVYYLKPS SPKHVRFSWH QDAVTVTCSD LSYGDLLYEV QYRSPFDTEW QSKQENTCNV TIEGLDAEKC YSFWVRVKAM EDVYGPDTYP SDWSEVTCWQ RGEIRDACAE TPTPPKPKLS KFILISSLAI LLMVSLLLLS LWKLWRVKKF LIPSVPDPKS IFPGLFEIHQ GNFQEWITDT QNVAHLHKMA GAEQESGPEE PLVVQLAKTE AESPRMLDPQ TEEKEASGGS LQLPHQPLQG GDVVTIGGFT FVMNDRSYVA L