CRIM1_HUMAN » Cysteine-rich motor neuron 1 protein

CRIM1_HUMAN » Cysteine-rich motor neuron 1 protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CRIM1_HUMAN » Cysteine-rich motor neuron 1 protein » CRIM-1; Cysteine-rich repeat-containing protein S52;
Hydrophobic Thickness 35.2 ± 3.2 Å
Tilt Angle 2 ± 6°
ΔGtransfer -25.0 kcal/mol
ΔGfold -18.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 937-961 (933-964)
Pathways none
PDB none
OPM none
Complexes none
Interactions

PLS1, Complex: PLS1:CRIM1, PubMed

Domains

AA: 37-90, PDBID: 1BOE, Subunit A, Seq Identity:42%, Insulin-like growth factor binding protein

AA: 336-390, PDBID: 1U5M, Subunit A, Seq Identity:38%, von Willebrand factor type C domain

AA: 403-456, PDBID: 1U5M, Subunit A, Seq Identity:35%, von Willebrand factor type C domain

AA: 469-498, Antistasin family

AA: 505-532, Antistasin family

AA: 539-564, Antistasin family

AA: 567-592, Antistasin family

AA: 608-662, PDBID: 1U5M, Subunit A, Seq Identity:35%, von Willebrand factor type C domain

AA: 679-734, PDBID: 1U5M, Subunit A, Seq Identity:30%, von Willebrand factor type C domain

AA: 753-808, PDBID: 1U5M, Subunit A, Seq Identity:30%, von Willebrand factor type C domain

AA: 819-873, PDBID: 1U5M, Subunit A, Seq Identity:37%, von Willebrand factor type C domain

UniProt annotation for CRIM1_HUMAN » Cysteine-rich motor neuron 1 protein
FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

SUBUNIT: Interacts with BMP4 and BMP7.

TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).

UniProt features for CRIM1_HUMAN » Cysteine-rich motor neuron 1 protein
SIGNAL 1 34
CHAIN 35 1036 Cysteine-rich motor neuron 1 protein.
CHAIN ? 1036 Processed cysteine-rich motor neuron 1 protein.
DOMAIN 35 112 IGFBP N-terminal.
DOMAIN 334 391 VWFC 1.
DOMAIN 401 457 VWFC 2.
DOMAIN 469 498 Antistasin-like 1.
DOMAIN 505 532 Antistasin-like 2.
DOMAIN 539 564 Antistasin-like 3.
DOMAIN 567 592 Antistasin-like 4.
DOMAIN 606 663 VWFC 3.
DOMAIN 677 735 VWFC 4.
DOMAIN 751 809 VWFC 5.
DOMAIN 817 874 VWFC 6.
MOTIF 314 316 Cell attachment site (Potential).
Amino Acid Sequence for CRIM1_HUMAN » Cysteine-rich motor neuron 1 protein
MYLVAGDRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPRN CPGSIVQGVC GCCYTCASQR NESCGGTFGI YGTCDRGLRC VIRPPLNGDS LTEYEAGVCE DENWTDDQLL GFKPCNENLI AGCNIINGKC ECNTIRTCSN PFEFPSQDMC LSALKRIEEE KPDCSKARCE VQFSPRCPED SVLIEGYAPP GECCPLPSRC VCNPAGCLRK VCQPGNLNIL VSKASGKPGE CCDLYECKPV FGVDCRTVEC PPVQQTACPP DSYETQVRLT ADGCCTLPTR CECLSGLCGF PVCEVGSTPR IVSRGDGTPG KCCDVFECVN DTKPACVFNN VEYYDGDMFR MDNCRFCRCQ GGVAICFTAQ CGEINCERYY VPEGECCPVC EDPVYPFNNP AGCYANGLIL AHGDRWREDD CTFCQCVNGE RHCVATVCGQ TCTNPVKVPG ECCPVCEEPT IITVDPPACG ELSNCTLTGK DCINGFKRDH NGCRTCQCIN TEELCSERKQ GCTLNCPFGF LTDAQNCEIC ECRPRPKKCR PIICDKYCPL GLLKNKHGCD ICRCKKCPEL SCSKICPLGF QQDSHGCLIC KCREASASAG PPILSGTCLT VDGHHHKNEE SWHDGCRECY CLNGREMCAL ITCPVPACGN PTIHPGQCCP SCADDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDQPFR PSLSRNNSVP NYCKNDEGDI FLAAESWKPD VCTSCICIDS VISCFSESCP SVSCERPVLR KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDLDSCTHC YCLQGQTLCS TVSCPPLPCV EPINVEGSCC PMCPEMYVPE PTNIPIEKTN HRGEVDLEVP LWPTPSENDI VHLPRDMGHL QVDYRDNRLH PSEDSSLDSI ASVVVPIIIC LSIIIAFLFI NQKKQWIPLL CWYRTPTKPS SLNNQLVSVD CKKGTRVQVD SSQRMLRIAE PDARFSGFYS MQKQNHLQAD NFYQTV