COX7B_HUMAN » Cytochrome c oxidase subunit 7B, mitochondrial

COX7B_HUMAN » Cytochrome c oxidase subunit 7B, mitochondrial
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
COX7B_HUMAN » Cytochrome c oxidase subunit 7B, mitochondrial » Cytochrome c oxidase polypeptide VIIb;
Hydrophobic Thickness 27.0 ± 1.2 Å
Tilt Angle 0 ± 2°
ΔGtransfer -14.5 kcal/mol
ΔGfold -5.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 38-57 (35-59)
Pathways

Alzheimer's disease (KEGG)

Cardiac muscle contraction (KEGG)

Huntington's disease (KEGG)

Oxidative phosphorylation (KEGG)

Parkinson's disease (KEGG)

PDB none
OPM 2dyr (BOVIN), 2ybb (BOVIN)
Complexes

COX1:COX3:COX41:COX5A:COX5B:CX6B1:COX7C:COX6C:CX7A1:CX6A2:COX8B:COX7B:COX2_BOVIN

QCR10:CYC:COX1:COX3:COX41:COX5A:COX5B:CX6B1:COX7C:COX6C:CX7A1:CX6A2:COX8B:COX7B:COX2:CY1:QCR6:QCR7:QCR9:CYB:QCR8:UCRI:QCR2:QCR1:NQO6:NQO5:NQO4:NQO2:NQO1:NQO3:NQO9:NQO15_BOVIN

Interactions

COX41, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

COX6C, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

COX7C, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

CX6A2, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

CX7A1, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

UCRI, Complex: Mitochondrial supercomplex, PDBID: 2YBB

Domains

AA: 1-79, PDBID: 1OCC, Subunit K, Seq Identity:78%, Cytochrome C oxidase chain VIIB

UniProt annotation for COX7B_HUMAN » Cytochrome c oxidase subunit 7B, mitochondrial
FUNCTION: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates.

DISEASE: Aplasia cutis congenita, reticulolinear, with microcephaly, facial dysmorphism and other congenital anomalies (APLCC) OMIM: A distinct form of aplasia cutis congenita presenting as multiple linear skin defects on the face and neck associated with poor growth, microcephaly, and facial dysmorphism. Additional features include intellectual disability, nail dystrophy, short stature and cardiac abnormalities. mutations affecting the gene represented in this entry.

UniProt features for COX7B_HUMAN » Cytochrome c oxidase subunit 7B, mitochondrial
TRANSIT 1 24 Mitochondrion.
CHAIN 25 80 Cytochrome c oxidase subunit 7B, mitochondrial.
Amino Acid Sequence for COX7B_HUMAN » Cytochrome c oxidase subunit 7B, mitochondrial
MFPLVKSALN RLQVRSIQQT MARQSHQKRT PDFHDKYGNA VLASGATFCI VTWTYVATQV GIEWNLSPVG RVTPKEWRNQ