COX6C_HUMAN » Cytochrome c oxidase subunit 6C

COX6C_HUMAN » Cytochrome c oxidase subunit 6C
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
COX6C_HUMAN » Cytochrome c oxidase subunit 6C » Cytochrome c oxidase polypeptide VIc;
Hydrophobic Thickness 29.0 ± 2.3 Å
Tilt Angle 18 ± 4°
ΔGtransfer -18.5 kcal/mol
ΔGfold -12.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 19-39 (14-46)
Pathways

Alzheimer's disease (KEGG)

Cardiac muscle contraction (KEGG)

Huntington's disease (KEGG)

Oxidative phosphorylation (KEGG)

Parkinson's disease (KEGG)

PDB none
OPM 2dyr (BOVIN), 2ybb (BOVIN)
Complexes

COX1:COX3:COX41:COX5A:COX5B:CX6B1:COX7C:COX6C:CX7A1:CX6A2:COX8B:COX7B:COX2_BOVIN

QCR10:CYC:COX1:COX3:COX41:COX5A:COX5B:CX6B1:COX7C:COX6C:CX7A1:CX6A2:COX8B:COX7B:COX2:CY1:QCR6:QCR7:QCR9:CYB:QCR8:UCRI:QCR2:QCR1:NQO6:NQO5:NQO4:NQO2:NQO1:NQO3:NQO9:NQO15_BOVIN

Interactions

COA3, Complex: COX6C:COA3

COX41, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

COX7B, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

COX7C, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

CX6A2, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

CX7A1, Complex: COX1:COX2:COX3:COX41:COX5A:COX5B:COX6C:COX7B:COX7C:CX6A2:CX7A1, PDBID: 1occ

NDUB8, Complex: NDUB8:COX6C

TIM21, Complex: TIM21:COX6C

UCRI, Complex: Mitochondrial supercomplex, PDBID: 2YBB

Domains

AA: 5-74, PDBID: 1OCC, Subunit V, Seq Identity:76%, Cytochrome c oxidase subunit VIc

UniProt annotation for COX6C_HUMAN » Cytochrome c oxidase subunit 6C
FUNCTION: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
UniProt features for COX6C_HUMAN » Cytochrome c oxidase subunit 6C
CHAIN 1 75 Cytochrome c oxidase subunit 6C.
Amino Acid Sequence for COX6C_HUMAN » Cytochrome c oxidase subunit 6C
MAPEVLPKPR MRGLLARRLR NHMAVAFVLS LGVAALYKFR VADQRKKAYA DFYRNYDVMK DFEEMRKAGI FQSVK