COPA1_HUMAN » Collagen alpha-1(XXV) chain

COPA1_HUMAN » Collagen alpha-1(XXV) chain
Magnify COPA1_HUMAN » Collagen alpha-1(XXV) chainEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
COPA1_HUMAN » Collagen alpha-1(XXV) chain » Alzheimer disease amyloid-associated protein;AMY; CLAC-P;
Hydrophobic Thickness 28.8 ± 2.0 Å
Tilt Angle 1 ± 0°
ΔGtransfer -34.3 kcal/mol
ΔGfold -13.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 31-52 (31-55)
Pathways

Extracellular matrix organization (Reactome)

PDB none
OPM none
Complexes none
Interactions

A4, Complex: COPA1:A4, PubMed

Domains

AA: 118-165, PDBID: 2JG8, Subunit C, Seq Identity:44%, Collagen triple helix repeat (20 copies)

AA: 310-372, PDBID: 2JG8, Subunit B, Seq Identity:47%, Collagen triple helix repeat (20 copies)

AA: 371-427, PDBID: 3GXE, Subunit F, Seq Identity:43%, Collagen triple helix repeat (20 copies)

AA: 447-505, PDBID: 3GXE, Subunit F, Seq Identity:43%, Collagen triple helix repeat (20 copies)

AA: 574-647, PDBID: 3GXE, Subunit F, Seq Identity:40%, Collagen triple helix repeat (20 copies)

UniProt annotation for COPA1_HUMAN » Collagen alpha-1(XXV) chain
FUNCTION: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.

SUBUNIT: Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40.

TISSUE SPECIFICITY: Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.

UniProt features for COPA1_HUMAN » Collagen alpha-1(XXV) chain
CHAIN 1 654 Collagen alpha-1(XXV) chain.
CHAIN 113 654 Collagen-like Alzheimer amyloid plaque component.
DOMAIN 121 164 Collagen-like 1.
DOMAIN 192 247 Collagen-like 2.
DOMAIN 249 308 Collagen-like 3.
DOMAIN 311 370 Collagen-like 4.
DOMAIN 372 425 Collagen-like 5.
DOMAIN 447 505 Collagen-like 6.
DOMAIN 571 630 Collagen-like 7.
REGION 181 188 Interaction with beta amyloid peptide.
SITE 112 113 Cleavage; by furin.
Amino Acid Sequence for COPA1_HUMAN » Collagen alpha-1(XXV) chain
MLLKKHAGKG GGREPRSEDP TPAEQHCSRT MPPCAVLAAL LSVVAVVSCL YLGVKTNDLQ ARIAALESAK GAPSIHLLPD TLDHLKTMVQ EKVERLLAQK SYEHMAKIRI AREAPSECNC PAGPPGKRGK RGRRGESGPP GQPGPQGPPG PKGDKGEQGD QGPRMVFPKI NHGFLSADQQ LIKRRLIKGD QGQAGPPGPP GPPGPRGPPG DTGKDGPRGM PGVPGEPGKP GEQGLMGPLG PPGQKGSIGA PGIPGMNGQK GEPGLPGAVG QNGIPGPKGE PGEQGEKGDA GENGPKGDTG EKGDPGSSAA GIKGEPGESG RPGQKGEPGL PGLPGLPGIK GEPGFIGPQG EPGLPGLPGT KGERGEAGPP GRGERGEPGA PGPKGKQGES GTRGPKGSKG DRGEKGDSGA QGPRGPPGQK GDQGATKIID YNGNLHEALQ RITTLTVTGP PGPPGPQGLQ GPKGEQGSPG IPGMDGEQGL KGSKGDMGDP GMTGEKGGIG LPGLPGANGM KGEKGDSGMP GPQGPSIIGP PGPPGPHGPP GPMGPHGLPG PKGTDGPMGP HGPAGPKGER GEKGAMGEPG PRGPYGLPGK DGEPGLDGFP GPRGEKGDLG EKGEKGFRGV KGEKGEPGQP GLDGLDAPCQ LGPDGLPMPG CWQK