COMC_DICDI » EGF-like domain-containing protein comC

COMC_DICDI » EGF-like domain-containing protein comC
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
COMC_DICDI » EGF-like domain-containing protein comC » Communication mutant protein C;
Hydrophobic Thickness 28.8 ± 2.8 Å
Tilt Angle 0 ± 2°
ΔGtransfer -27.1 kcal/mol
ΔGfold -11.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 1448-1470 (1447-1473)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 749-781, PDBID: 4Z80, Subunit A, Seq Identity:41%, EGF-like domain

AA: 819-851, PDBID: 3G5C, Subunit B, Seq Identity:30%, EGF-like domain

AA: 1165-1193, PDBID: 4Z80, Subunit A, Seq Identity:48%, EGF-like domain
UniProt annotation for COMC_DICDI » EGF-like domain-containing protein comC
FUNCTION: Regulates aggregation via a pathway that involves lagC and tgrD1/lagD. Inhibits lagC and activates lagD expression.

DEVELOPMENTAL STAGE: Expressed from early development; required for aggregation prior to fruiting body formation and sporulation.

INDUCTION: Down-regulated by Pseudomonas aeruginosa, PAO1 strain and up-regulated by PA14 strain infection.

UniProt features for COMC_DICDI » EGF-like domain-containing protein comC
SIGNAL 1 20 Potential.
CHAIN 21 1501 EGF-like domain-containing protein comC.
DOMAIN 627 661 EGF-like 1.
DOMAIN 782 816 EGF-like 2.
DOMAIN 818 852 EGF-like 3.
DOMAIN 896 933 EGF-like 4.
DOMAIN 975 1008 EGF-like 5.
DOMAIN 1043 1077 EGF-like 6.
DOMAIN 1161 1194 EGF-like 7.
DISULFID 631 642 By similarity.
DISULFID 636 649 By similarity.
DISULFID 651 660 By similarity.
DISULFID 786 797 By similarity.
DISULFID 791 804 By similarity.
DISULFID 806 815 By similarity.
DISULFID 822 833 By similarity.
DISULFID 827 840 By similarity.
DISULFID 842 851 By similarity.
DISULFID 900 914 By similarity.
DISULFID 908 921 By similarity.
DISULFID 923 932 By similarity.
DISULFID 979 989 By similarity.
DISULFID 983 996 By similarity.
DISULFID 998 1007 By similarity.
DISULFID 1047 1058 By similarity.
DISULFID 1052 1065 By similarity.
DISULFID 1067 1076 By similarity.
DISULFID 1165 1175 By similarity.
DISULFID 1169 1182 By similarity.
DISULFID 1184 1193 By similarity.
Amino Acid Sequence for COMC_DICDI » EGF-like domain-containing protein comC
MIKKYLFLFF IFLIFNFVLS IQPPLSEYNC LKNFVTKFKL STKFPTNSTG GYDFCSIVSC NPVNGSINGF LSLQSESTTP TTVTVVGTDL SCLPFNNLNL QNFLISTTLL YTKFFTSCST LAINSDSITS ITQVLAPYET FTIVSKKLNG ALKMSNFINQ KSILITNSNS TSGYTLVNDA LAENKIKLET PNFSGLLSVP DLTGYTSLGY PAFYFSDALE VTSLALANIK TIGAVSSRLY FPSTKTIQFP TSYHNDTSYL TIQGKFTKPT AVIDLSKFVN CRNIQILNYD KTFNINGEIP IKTSPFTDIY YTDGNITKIP IGGTSFVTWS TEQSITIKKS GLSGTLPPLS GVIPTYYDFS GNSISGTLSN TWCNTNIIVT DNLMTGTLPS CIVCHLNNSE VAKKFTGNKF TNLVTSNPPC TTFAPKIKVD KSQKTIILTG TDFGTYTSGW ILNTTLSCEK LWTKVTYGSN YTCTYPSTTT LDKVSYFWIN FNTPGRNYTF PAISQVPTPN SIIVGTSNSV TISGTFFSTY IGYVTQSISV GSISCTVGTS SFSSITCTLD SAPSTNTEQK LIITTNSLIK EAYISTVVGF NNNKLCPNDC TSSTRGICYM NNGTCKCNSG YVGLDCSGLQ CKVPNCSNGG TCNTTVGLCV CDSSHQSLDC SLDFKQCPKG LNSLICSGGG NSCNNQTGIC TCNSSHQGLN CSINYKQCPI GSNSLICSGG GNSCNNQTGI CKCDSSHQGS DCANDFIQCP LKNSIPCSGH GICNNKTGDC TCDSGFTNQD CSGYTCTSNN CNGHGVCDTS KGICQCYPEW QDIDCQTPFK NCLDPTCSNN GICKNTTGIC ECNSSHQGLT CSIDFNQCPI GSNSLICSGG SGNICNNQTG ICTCDSSHQG PDCGTDFIKC PTQNLTPCNG FGNCNNITGS CSCDQNHQSE DCNIVYKECP IINSLICNGF DNSCNNQTGV CTCDDLHQGL DCGLEYKPCI NNCNGNGVCN NQTSICTCYE AYQGETCQFQ INQCPNNCTT GGDCDTITGI CNCYPLRINN DCSGYECLDP NCGDHGICND MNGLCICDKG YRGDNCIYVD HYASSVIPTK EEGGTVLIYG LFGEINNDPN VQVGNSNCLI SNITSNSIEC IIGKGSGIKD ISVTQNGFEW IGKSMFNYIK SKQSCPNNCN SNGICNDLQG KCECYPGFTG HDCNSLSKTD LISPSTPKVN ENTANGIIEN GENKFEIMVI TLQEKTFTNG VLKQYNLENN WKLLEIINDE NNNIFKFKQN LTDSSEISIN LEIIKKDRII NFADYSFEIS KDSIKVSINI SNYIYSNSLN YLQLHLKSNA YKTNKTSSDD EFDCNLDDGS DAKIDNQDLE NSNINHENFV TIIKDNKILN GRYIDHVISD GISTFISSRT IEKDSNSITV GLNLPHCKNC LIDPDFSVLL STDFKENCSD SNSNNYIIPV SITVSIGGAA VLVGSAIFFY RKKFIENTLK IQLKRLSKNN SSGSDGGNTQ S