COL12_HUMAN » Collectin-12

COL12_HUMAN » Collectin-12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
COL12_HUMAN » Collectin-12 » Collectin placenta protein 1;CL-P1; hCL-P1; Nurse cell scavenger receptor 2;Scavenger receptor class A member 4;Scavenger receptor with C-type lectin;
Hydrophobic Thickness 38.0 ± 3.2 Å
Tilt Angle 30 ± 1°
ΔGtransfer -28.5 kcal/mol
ΔGfold -22.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 34-62 (33-65)
Pathways

Phagosome (KEGG)

PDB 2ox8 (607-742)
OPM none
Complexes none
Interactions

A4, Complex: A4:COL12, PubMed

Domains

AA: 441-499, PDBID: 2R6Q, Subunit A, Seq Identity:45%, Collagen triple helix repeat (20 copies)

AA: 530-589, PDBID: 3GXE, Subunit F, Seq Identity:51%, Collagen triple helix repeat (20 copies)

AA: 624-732, PDBID: 2OX8, Subunit C, Seq Identity:100%, Lectin C-type domain

UniProt annotation for COL12_HUMAN » Collectin-12
FUNCTION: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.

SUBUNIT: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid peptide.

TISSUE SPECIFICITY: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.

UniProt features for COL12_HUMAN » Collectin-12
CHAIN 1 742 Collectin-12.
DOMAIN 443 472 Collagen-like 1.
DOMAIN 473 529 Collagen-like 2.
DOMAIN 530 589 Collagen-like 3.
DOMAIN 614 731 C-type lectin.
COILED 73 141 Potential.
COILED 215 328 Potential.
DISULFID 607 618
DISULFID 635 730
DISULFID 708 722
Amino Acid Sequence for COL12_HUMAN » Collectin-12
MKDDFAEEEE VQSFGYKRFG IQEGTQCTKC KNNWALKFSI ILLYILCALL TITVAILGYK VVEKMDNVTG GMETSRQTYD DKLTAVESDL KKLGDQTGKK AISTNSELST FRSDILDLRQ QLREITEKTS KNKDTLEKLQ ASGDALVDRQ SQLKETLENN SFLITTVNKT LQAYNGYVTN LQQDTSVLQG NLQNQMYSHN VVIMNLNNLN LTQVQQRNLI TNLQRSVDDT SQAIQRIKND FQNLQQVFLQ AKKDTDWLKE KVQSLQTLAA NNSALAKANN DTLEDMNSQL NSFTGQMENI TTISQANEQN LKDLQDLHKD AENRTAIKFN QLEERFQLFE TDIVNIISNI SYTAHHLRTL TSNLNEVRTT CTDTLTKHTD DLTSLNNTLA NIRLDSVSLR MQQDLMRSRL DTEVANLSVI MEEMKLVDSK HGQLIKNFTI LQGPPGPRGP RGDRGSQGPP GPTGNKGQKG EKGEPGPPGP AGERGPIGPA GPPGERGGKG SKGSQGPKGS RGSPGKPGPQ GPSGDPGPPG PPGKEGLPGP QGPPGFQGLQ GTVGEPGVPG PRGLPGLPGV PGMPGPKGPP GPPGPSGAVV PLALQNEPTP APEDNGCPPH WKNFTDKCYY FSVEKEIFED AKLFCEDKSS HLVFINTREE QQWIKKQMVG RESHWIGLTD SERENEWKWL DGTSPDYKNW KAGQPDNWGH GHGPGEDCAG LIYAGQWNDF QCEDVNNFIC EKDRETVLSS AL