COA3_YEAST » Cytochrome c oxidase assembly protein 3, mitochondrial

COA3_YEAST » Cytochrome c oxidase assembly protein 3, mitochondrial
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
COA3_YEAST » Cytochrome c oxidase assembly protein 3, mitochondrial » COX25; Cytochrome c oxidase protein 25;Required for respiratory growth protein 10;
Hydrophobic Thickness 31.6 ± 2.7 Å
Tilt Angle 8 ± 7°
ΔGtransfer -17.4 kcal/mol
ΔGfold -4.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 27-49 (26-50)
Pathways none
PDB none
OPM none
Complexes none
Interactions

COA1, Complex: COA3:COA1, PubMed

COX11, Complex: COX11:COA3

COX14, Complex: COA3:COX14, PubMed

COX5A, Complex: COX5A:COA3, PubMed

COX5B, Complex: COX5B:COA3, PubMed

MNN1, Complex: G6PI:EF2:LPLA:TRX1:YM94:HGH1:DPH1:DPH2:MNN1:COA3, PubMed

Domains none
UniProt annotation for COA3_YEAST » Cytochrome c oxidase assembly protein 3, mitochondrial
FUNCTION: Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.

SUBUNIT: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51.

MISCELLANEOUS: Present with 2530 molecules/cell in log phase SD medium.

UniProt features for COA3_YEAST » Cytochrome c oxidase assembly protein 3, mitochondrial
CHAIN 1 85 Cytochrome c oxidase assembly protein 3, mitochondrial.
Amino Acid Sequence for COA3_YEAST » Cytochrome c oxidase assembly protein 3, mitochondrial
MVLNPSKYQD TRTWKMTPAM IRARKPFFKG NMLGLTLLLG VTGSVYYYTY HFLHKDNDFA DVPIPPIDPQ ELEALKKEYE AKKKA