COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial

COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial » COX25;Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa;
Hydrophobic Thickness 33.4 ± 3.8 Å
Tilt Angle 0 ± 3°
ΔGtransfer -18.1 kcal/mol
ΔGfold -12.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 56-78 (51-81)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CD052, Complex: SMI20:COA3

COA1, Complex: COA1:COA3

COX11, Complex: COX11:COA3

COX14, Complex: COA3:COX14

COX16, Complex: COX16:COA3

COX41, Complex: COA3:COX41

COX6C, Complex: COX6C:COA3

CX6A2, Complex: COA3:CX6A2

MAVS, Complex: MAVS:COA3

NDUC2, Complex: NDUC2:COA3

TIM21, Complex: TIM21:COA3
Domains

AA: 1-106, Coiled-coil domain-containing protein 56
UniProt annotation for COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial
FUNCTION: Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.

SUBUNIT: Component of some MITRAC complex.

UniProt features for COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial
CHAIN 1 106 Cytochrome c oxidase assembly protein 3 homolog, mitochondrial.
COILED 78 104 Potential.
Amino Acid Sequence for COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial
MASSGAGDPL DSKRGEAPFA QRIDPTREKL TPEQLHSMRQ AELAQWQKVL PRRRTRNIVT GLGIGALVLA IYGYTFYSIS QERFLDELED EAKAARARAL ARASGS