![]() | intermembrane space |
mitochondrial matrix side |
COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial » COX25;Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa; | |
---|---|
Hydrophobic Thickness | 33.4 ± 3.8 Å |
Tilt Angle | 0 ± 3° |
ΔGtransfer | -18.1 kcal/mol |
ΔGfold | -12.8 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC |
Topology | Out |
TM Segments | 56-78 (51-81) |
Pathways | none |
PDB | none |
OPM | none |
Complexes | none |
Interactions | CD052, Complex: SMI20:COA3 COA1, Complex: COA1:COA3 COX11, Complex: COX11:COA3 COX14, Complex: COA3:COX14 COX16, Complex: COX16:COA3 COX41, Complex: COA3:COX41 COX6C, Complex: COX6C:COA3 CX6A2, Complex: COA3:CX6A2 MAVS, Complex: MAVS:COA3 NDUC2, Complex: NDUC2:COA3 TIM21, Complex: TIM21:COA3 |
Domains | AA: 1-106, Coiled-coil domain-containing protein 56 |
UniProt annotation for COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial |
---|
FUNCTION: Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. SUBUNIT: Component of some MITRAC complex. |
UniProt features for COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial |
---|
CHAIN 1 106 Cytochrome c oxidase assembly protein 3 homolog, mitochondrial. COILED 78 104 Potential. |
Amino Acid Sequence for COA3_HUMAN » Cytochrome c oxidase assembly protein 3 homolog, mitochondrial |
---|
MASSGAGDPL DSKRGEAPFA QRIDPTREKL TPEQLHSMRQ AELAQWQKVL PRRRTRNIVT GLGIGALVLA IYGYTFYSIS QERFLDELED EAKAARARAL ARASGS |