COA1_HUMAN » Cytochrome c oxidase assembly protein 1 homolog

COA1_HUMAN » Cytochrome c oxidase assembly protein 1 homolog
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
COA1_HUMAN » Cytochrome c oxidase assembly protein 1 homolog » Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa;
Hydrophobic Thickness 26.8 ± 3.4 Å
Tilt Angle 30 ± 0°
ΔGtransfer -18.5 kcal/mol
ΔGfold -8.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 20-40 (17-43)
Pathways none
PDB none
OPM none
Complexes none
Interactions

COA3, Complex: COA1:COA3

NDUB8, Complex: COA1:NDUB8

TIM21, Complex: COA1:TIM21

Domains

AA: 18-134, Cytochrome oxidase complex assembly protein 1

UniProt annotation for COA1_HUMAN » Cytochrome c oxidase assembly protein 1 homolog
FUNCTION: Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV.

SUBUNIT: Interacts with COX17 and COA6. Component of some MITRAC complex.

UniProt features for COA1_HUMAN » Cytochrome c oxidase assembly protein 1 homolog
CHAIN 1 146 Cytochrome c oxidase assembly protein 1 homolog.
Amino Acid Sequence for COA1_HUMAN » Cytochrome c oxidase assembly protein 1 homolog
MMWQKYAGSR RSMPLGARIL FHGVFYAGGF AIVYYLIQKF HSRALYYKLA VEQLQSHPEA QEALGPPLNI HYLKLIDREN FVDIVDAKLK IPVSGSKSEG LLYVHSSRGG PFQRWHLDEV FLELKDGQQI PVFKLSGENG DEVKKE