CNTP4_HUMAN » Contactin-associated protein-like 4

CNTP4_HUMAN » Contactin-associated protein-like 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CNTP4_HUMAN » Contactin-associated protein-like 4 » Cell recognition molecule Caspr4;
Hydrophobic Thickness 33.6 ± 1.6 Å
Tilt Angle 0 ± 1°
ΔGtransfer -48.4 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1241-1265 (1239-1268)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 41-174, PDBID: 1SDD, Subunit B, Seq Identity:34%, F5/8 type C domain

AA: 212-341, PDBID: 2R16, Subunit A, Seq Identity:21%, Laminin G domain

AA: 398-524, PDBID: 3SH4, Subunit A, Seq Identity:26%, Laminin G domain

AA: 821-940, PDBID: 3ASI, Subunit A, Seq Identity:31%, Laminin G domain

AA: 1046-1176, PDBID: 3SH4, Subunit A, Seq Identity:20%, Laminin G domain

UniProt annotation for CNTP4_HUMAN » Contactin-associated protein-like 4
FUNCTION: Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).

SUBUNIT: Interacts with TIAM1.

UniProt features for CNTP4_HUMAN » Contactin-associated protein-like 4
SIGNAL 1 25 Potential.
CHAIN 26 1308 Contactin-associated protein-like 4.
DOMAIN 31 177 F5/8 type C.
DOMAIN 212 364 Laminin G-like 1.
DOMAIN 398 547 Laminin G-like 2.
DOMAIN 549 586 EGF-like 1.
DOMAIN 587 792 Fibrinogen C-terminal.
DOMAIN 793 957 Laminin G-like 3.
DOMAIN 958 997 EGF-like 2.
DOMAIN 1046 1202 Laminin G-like 4.
DISULFID 31 177 By similarity.
DISULFID 332 364 By similarity.
DISULFID 515 547 By similarity.
DISULFID 553 564 By similarity.
DISULFID 558 573 By similarity.
DISULFID 575 585 By similarity.
DISULFID 931 958 By similarity.
DISULFID 962 975 By similarity.
DISULFID 969 984 By similarity.
DISULFID 986 996 By similarity.
DISULFID 1167 1202 By similarity.
Amino Acid Sequence for CNTP4_HUMAN » Contactin-associated protein-like 4
MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL SSSHGPGFAR LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY GSSNWVTSYL LMFSDSGWNW KQYRQEDSIW GFSGNANADS VVYYRLQPSI KARFLRFIPL EWNPKGRIGM RIEVFGCAYR SEVVDLDGKS SLLYRFDQKS LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR LFLLINSGEA KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE FNLMNLDYEI SFGGIPAPGK SVSFPHRNFH GCLENLYYNG VDIIDLAKQQ KPQIIAMGNV SFSCSQPQSM PVTFLSSRSY LALPDFSGEE EVSATFQFRT WNKAGLLLFS ELQLISGGIL LFLSDGKLKS NLYQPGKLPS DITAGVELND GQWHSVSLSA KKNHLSVAVD GQMASAAPLL GPEQIYSGGT YYFGGCPDKS FGSKCKSPLG GFQGCMRLIS ISGKVVDLIS VQQGSLGNFS DLQIDSCGIS DRCLPNYCEH GGECSQSWST FHCNCTNTGY RGATCHNSIY EQSCEAYKHR GNTSGFYYID SDGSGPLEPF LLYCNMTETA WTIIQHNGSD LTRVRNTNPE NPYAGFFEYV ASMEQLQATI NRAEHCEQEF TYYCKKSRLV NKQDGTPLSW WVGRTNETQT YWGGSSPDLQ KCTCGLEGNC IDSQYYCNCD ADRNEWTNDT GLLAYKEHLP VTKIVITDTG RLHSEAAYKL GPLLCQGDRS FWNSASFDTE ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGIADFI RIELRSPTVV TFSFDVGNGP FEISVQSPTH FNDNQWHHVR VERNMKEASL QVDQLTPKTQ PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGM TLDLEERAQV TPEVQPGCRG HCSSYGKLCR NGGKCRERPI GFFCDCTFSA YTGPFCSNEI SAYFGSGSSV IYNFQENYLL SKNSSSHAAS FHGDMKLSRE MIKFSFRTTR TPSLLLFVSS FYKEYLSVII AKNGSLQIRY KLNKYQEPDV VNFDFKNMAD GQLHHIMINR EEGVVFIEID DNRRRQVHLS SGTEFSAVKS LVLGRILEHS DVDQDTALAG AQGFTGCLSA VQLSHVAPLK AALHPSHPDP VTVTGHVTES SCMAQPGTDA TSRERTHSFA DHSGTIDDRE PLANAIKSDS AVIGGLIAVV IFILLCITAI AVRIYQQKRL YKRSEAKRSE NVDSAEAVLK SELNIQNAVN ENQKEYFF