CNTP1_HUMAN » Contactin-associated protein 1

CNTP1_HUMAN » Contactin-associated protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CNTP1_HUMAN » Contactin-associated protein 1 » Caspr; Caspr1; Neurexin IV;Neurexin-4;p190;
Hydrophobic Thickness 38.8 ± 3.4 Å
Tilt Angle 8 ± 7°
ΔGtransfer -34.9 kcal/mol
ΔGfold -27.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1280-1306 (1278-1309)
Pathways

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

NFASC, Complex: NFASC:CNTP1, PubMed

NLGN1, Complex: CNTP1:NLGN1, PubMed

PTPRB, Complex: PTPRB:CNTP1, PubMed

Domains

AA: 37-165, PDBID: 4MO3, Subunit M, Seq Identity:32%, F5/8 type C domain

AA: 203-332, PDBID: 2H0B, Subunit B, Seq Identity:24%, Laminin G domain

AA: 389-515, PDBID: 2R16, Subunit A, Seq Identity:21%, Laminin G domain

AA: 813-939, PDBID: 3B3Q, Subunit E, Seq Identity:23%, Laminin G domain

AA: 1088-1218, PDBID: 3ASI, Subunit A, Seq Identity:23%, Laminin G domain

UniProt annotation for CNTP1_HUMAN » Contactin-associated protein 1
FUNCTION: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

SUBUNIT: Interacts with contactin in cis form.

TISSUE SPECIFICITY: Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

UniProt features for CNTP1_HUMAN » Contactin-associated protein 1
SIGNAL 1 19 Potential.
CHAIN 20 1384 Contactin-associated protein 1.
DOMAIN 25 168 F5/8 type C.
DOMAIN 203 355 Laminin G-like 1.
DOMAIN 389 538 Laminin G-like 2.
DOMAIN 540 577 EGF-like 1.
DOMAIN 576 795 Fibrinogen C-terminal.
DOMAIN 813 956 Laminin G-like 3.
DOMAIN 957 996 EGF-like 2.
DOMAIN 1088 1250 Laminin G-like 4.
MOTIF 1328 1369 SH3-binding (Potential).
DISULFID 25 168 By similarity.
DISULFID 323 355 By similarity.
DISULFID 506 538 By similarity.
DISULFID 544 555 By similarity.
DISULFID 549 564 By similarity.
DISULFID 566 576 By similarity.
DISULFID 930 957 By similarity.
DISULFID 961 974 By similarity.
DISULFID 968 983 By similarity.
DISULFID 985 995 By similarity.
DISULFID 1209 1250 By similarity.
Amino Acid Sequence for CNTP1_HUMAN » Contactin-associated protein 1
MMHLRLFCIL LAAVSGAEGW GYYGCDEELV GPLYARSLGA SSYYSLLTAP RFARLHGISG WSPRIGDPNP WLQIDLMKKH RIRAVATQGS FNSWDWVTRY MLLYGDRVDS WTPFYQRGHN STFFGNVNES AVVRHDLHFH FTARYIRIVP LAWNPRGKIG LRLGLYGCPY KADILYFDGD DAISYRFPRG VSRSLWDVFA FSFKTEEKDG LLLHAEGAQG DYVTLELEGA HLLLHMSLGS SPIQPRPGHT TVSAGGVLND QHWHYVRVDR FGRDVNFTLD GYVQRFILNG DFERLNLDTE MFIGGLVGAA RKNLAYRHNF RGCIENVIFN RVNIADLAVR RHSRITFEGK VAFRCLDPVP HPINFGGPHN FVQVPGFPRR GRLAVSFRFR TWDLTGLLLF SRLGDGLGHV ELTLSEGQVN VSIAQSGRKK LQFAAGYRLN DGFWHEVNFV AQENHAVISI DDVEGAEVRV SYPLLIRTGT SYFFGGCPKP ASRWDCHSNQ TAFHGCMELL KVDGQLVNLT LVEGRRLGFY AEVLFDTCGI TDRCSPNMCE HDGRCYQSWD DFICYCELTG YKGETCHTPL YKESCEAYRL SGKTSGNFTI DPDGSGPLKP FVVYCDIREN RAWTVVRHDR LWTTRVTGSS MERPFLGAIQ YWNASWEEVS ALANASQHCE QWIEFSCYNS RLLNTAGGYP YSFWIGRNEE QHFYWGGSQP GIQRCACGLD RSCVDPALYC NCDADQPQWR TDKGLLTFVD HLPVTQVVIG DTNRSTSEAQ FFLRPLRCYG DRNSWNTISF HTGAALRFPP IRANHSLDVS FYFRTSAPSG VFLENMGGPY CQWRRPYVRV ELNTSRDVVF AFDVGNGDEN LTVHSDDFEF NDDEWHLVRA EINVKQARLR VDHRPWVLRP MPLQTYIWME YDQPLYVGSA ELKRRPFVGC LRAMRLNGVT LNLEGRANAS EGTSPNCTGH CAHPRLPCFH GGRCVERYSY YTCDCDLTAF DGPYCNHDIG GFFEPGTWMR YNLQSALRSA AREFSHMLSR PVPGYEPGYI PGYDTPGYVP GYHGPGYRLP DYPRPGRPVP GYRGPVYNVT GEEVSFSFST SSAPAVLLYV SSFVRDYMAV LIKDDGTLQL RYQLGTSPYV YQLTTRPVTD GQPHSINITR VYRNLFIQVD YFPLTEQKFS LLVDSQLDSP KALYLGRVME TGVIDPEIQR YNTPGFSGCL SGVRFNNVAP LKTHFRTPRP MTAELAEALR VQGELSESNC GAMPRLVSEV PPELDPWYLP PDFPYYHDEG WVAILLGFLV AFLLLGLVGM LVLFYLQNHR YKGSYHTNEP KAAHEYHPGS KPPLPTSGPA QVPTPTAAPN QAPASAPAPA PTPAPAPGPR DQNLPQILEE SRSE