CNST_HUMAN » Consortin

CNST_HUMAN » Consortin
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
CNST_HUMAN » Consortin »
Hydrophobic Thickness 34.0 ± 2.4 Å
Tilt Angle 29 ± 0°
ΔGtransfer -22.9 kcal/mol
ΔGfold -13.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 664-689 (664-694)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 612-723, Consortin C-terminus

UniProt annotation for CNST_HUMAN » Consortin
FUNCTION: Required for targeting of connexins to the plasma membrane.

SUBUNIT: Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1 (By similarity).

UniProt features for CNST_HUMAN » Consortin
CHAIN 1 725 Consortin.
Amino Acid Sequence for CNST_HUMAN » Consortin
MDDSDTPTYY LQIEPQDGCH PGDSVERSVT CLPSASDENE NQLDGDGHEH LTSSDSAMGK PQVSEQDSLN NNESCTLSCE VAAGENSQNT LCEASRDEQA FLGKDKKIPG KRSPRSKKGT AKKIPPGLFS GDIAPLMQEK VLSAVTYAVD DEEAAEVNAN EQPEAPKLVL QSLFSLIRGE VEQLDSRALP LCLHQIAESY FQEEDYEKAM KFIQLERLYH EQLLANLSAI QEQWETKWKT VQPHTVTALR NSEKGFNGED FERLTKICAT HQDPLLSKHK IAAVEKSQER KCSTQLLVSE DPKEGGATTK ESESKTCLGT ESSKESQHTV EPLGSSPCCH QMDVQTDSPS LSVTAGKDHM EELLCSAEAT LALHTQSSET AGSPSGPDSS EDACEDDSRL QLAQTEACQD VARIEGIAED PKVFLSSKSK TEPLISPGCD RIPPALISEG KYSQAQRKEL RLPLRDASEA LPTDQLENNE LNELQQPDLT DSDGKSPQAQ ADSDGSENVL CGNNQISDLG ILLPEVCMAP EEKGDKDDQL NKETEDYLNS LLEGCLKDTE DSLSYEDNQD DDSDLLQDLS PEEASYSLQE NLPSDESCLS LDDLAKRIEI AEVVPTEGLV SILKKRNDTV GDHPAQMQHK PSKRRVRFQE IDDSLDQDEV GGGSCILLVL LCIATVFLSV GGTALYCTFG DMESPVCTDF ADNMDFYYTK LLQGVAELKH WIYLS