CNEP1_HUMAN » CTD nuclear envelope phosphatase 1

CNEP1_HUMAN » CTD nuclear envelope phosphatase 1
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
CNEP1_HUMAN » CTD nuclear envelope phosphatase 1 » Serine/threonine-protein phosphatase dullard;
Hydrophobic Thickness 31.0 ± 4.0 Å
Tilt Angle 11 ± 8°
ΔGtransfer -16.0 kcal/mol
ΔGfold -7.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 6-28 (3-32)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 62-231, PDBID: 2HHL, Subunit A, Seq Identity:36%, NLI interacting factor-like phosphatase

UniProt annotation for CNEP1_HUMAN » CTD nuclear envelope phosphatase 1
FUNCTION: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.

CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

SUBUNIT: Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.

TISSUE SPECIFICITY: Muscle specific with lower expression in other metabolic tissues.

UniProt features for CNEP1_HUMAN » CTD nuclear envelope phosphatase 1
CHAIN 1 244 CTD nuclear envelope phosphatase 1.
DOMAIN 57 224 FCP1 homology.
Amino Acid Sequence for CNEP1_HUMAN » CTD nuclear envelope phosphatase 1
MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP VSRNRLAQVK RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV VSQWYELVVF TASMEIYGSA VADKLDNSRS ILKRRYYRQH CTLELGSYIK DLSVVHSDLS SIVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW