CLV1_ARATH » Receptor protein kinase CLAVATA1

CLV1_ARATH » Receptor protein kinase CLAVATA1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLV1_ARATH » Receptor protein kinase CLAVATA1 »
Hydrophobic Thickness 33.2 ± 2.5 Å
Tilt Angle 25 ± 11°
ΔGtransfer -21.0 kcal/mol
ΔGfold -17.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 638-659 (638-665)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ACR4L, Complex: ACR4L:CLV1

BAME1, Complex: BAME1:CLV1

BAME2, Complex: BAME2:CLV1

CLV2, Complex: CLV2:CLV1, PubMed

CRN, Complex: CLV1:CRN

P2C70, Complex: CLV1:P2C70, PubMed

RPK2, Complex: CLV1:RPK2

Domains

AA: 24-67, PDBID: 3RGX, Subunit A, Seq Identity:33%, Leucine rich repeat N-terminal domain

AA: 528-588, PDBID: 3RGX, Subunit A, Seq Identity:43%, Leucine rich repeat

AA: 692-967, PDBID: 1FMK, Subunit A, Seq Identity:38%, Protein tyrosine kinase

UniProt annotation for CLV1_ARATH » Receptor protein kinase CLAVATA1
FUNCTION: Involved in the detection of CLV3 and CLV3-like peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Self-interacts. Interacts with CRN; this interaction is direct. Interacts with CLV3 and CLE2 mature peptides (MCLV3 and CLE2p, respectively) via its extracellular leucine-rich repeat region.

TISSUE SPECIFICITY: In a central region of the shoot and in early flower meristems.

UniProt features for CLV1_ARATH » Receptor protein kinase CLAVATA1
SIGNAL 1 24 Potential.
CHAIN 25 980 Receptor protein kinase CLAVATA1.
REPEAT 93 119 LRR 1.
REPEAT 143 167 LRR 2.
REPEAT 168 193 LRR 3.
REPEAT 240 264 LRR 4.
REPEAT 265 288 LRR 5.
REPEAT 289 312 LRR 6.
REPEAT 314 336 LRR 7.
REPEAT 337 360 LRR 8.
REPEAT 361 384 LRR 9.
REPEAT 386 408 LRR 10.
REPEAT 409 432 LRR 11.
REPEAT 455 479 LRR 12.
REPEAT 480 503 LRR 13.
REPEAT 505 527 LRR 14.
REPEAT 528 551 LRR 15.
REPEAT 552 575 LRR 16.
REPEAT 577 600 LRR 17.
REPEAT 675 691 LRR 18.
DOMAIN 692 968 Protein kinase.
ACT_SITE 817 817 Proton acceptor (By similarity).
Amino Acid Sequence for CLV1_ARATH » Receptor protein kinase CLAVATA1
MAMRLLKTHL LFLHLYLFFS PCFAYTDMEV LLNLKSSMIG PKGHGLHDWI HSSSPDAHCS FSGVSCDDDA RVISLNVSFT PLFGTISPEI GMLTHLVNLT LAANNFTGEL PLEMKSLTSL KVLNISNNGN LTGTFPGEIL KAMVDLEVLD TYNNNFNGKL PPEMSELKKL KYLSFGGNFF SGEIPESYGD IQSLEYLGLN GAGLSGKSPA FLSRLKNLRE MYIGYYNSYT GGVPPEFGGL TKLEILDMAS CTLTGEIPTS LSNLKHLHTL FLHINNLTGH IPPELSGLVS LKSLDLSINQ LTGEIPQSFI NLGNITLINL FRNNLYGQIP EAIGELPKLE VFEVWENNFT LQLPANLGRN GNLIKLDVSD NHLTGLIPKD LCRGEKLEML ILSNNFFFGP IPEELGKCKS LTKIRIVKNL LNGTVPAGLF NLPLVTIIEL TDNFFSGELP VTMSGDVLDQ IYLSNNWFSG EIPPAIGNFP NLQTLFLDRN RFRGNIPREI FELKHLSRIN TSANNITGGI PDSISRCSTL ISVDLSRNRI NGEIPKGINN VKNLGTLNIS GNQLTGSIPT GIGNMTSLTT LDLSFNDLSG RVPLGGQFLV FNETSFAGNT YLCLPHRVSC PTRPGQTSDH NHTALFSPSR IVITVIAAIT GLILISVAIR QMNKKKNQKS LAWKLTAFQK LDFKSEDVLE CLKEENIIGK GGAGIVYRGS MPNNVDVAIK RLVGRGTGRS DHGFTAEIQT LGRIRHRHIV RLLGYVANKD TNLLLYEYMP NGSLGELLHG SKGGHLQWET RHRVAVEAAK GLCYLHHDCS PLILHRDVKS NNILLDSDFE AHVADFGLAK FLVDGAASEC MSSIAGSYGY IAPEYAYTLK VDEKSDVYSF GVVLLELIAG KKPVGEFGEG VDIVRWVRNT EEEITQPSDA AIVVAIVDPR LTGYPLTSVI HVFKIAMMCV EEEAAARPTM REVVHMLTNP PKSVANLIAF