CLMP_HUMAN » CXADR-like membrane protein

CLMP_HUMAN » CXADR-like membrane protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLMP_HUMAN » CXADR-like membrane protein » Adipocyte adhesion molecule;Coxsackie- and adenovirus receptor-like membrane protein;CAR-like membrane protein;
Hydrophobic Thickness 38.8 ± 1.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -52.2 kcal/mol
ΔGfold -24.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 233-258 (225-262)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 18-129, PDBID: 3JZ7, Subunit A, Seq Identity:30%, Immunoglobulin V-set domain

AA: 129-225, PDBID: 1F2Q, Subunit A, Seq Identity:21%, Immunoglobulin domain

UniProt annotation for CLMP_HUMAN » CXADR-like membrane protein
FUNCTION: May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.

TISSUE SPECIFICITY: Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level).

DEVELOPMENTAL STAGE: At 7 and 8 weeks of development, it is highly abundant in the rapidly dividing cells of the central and peripheral nervous systems, the mesenchyme of the frontonasal and mandibular processes and the dermamyotome, and it is expressed in the endodermal derivatives of the foregut, midgut, and hindgut, as well as in the liver, lung, esophagus, and trachea. During midterm fetal stages, 18 and 23 weeks of development, increased expression is observed in the intestinal crypts. Midterm liver and kidney tissues strongly express CLMP in the parenchyma of the lobules and cortex, respectively.

INDUCTION: Up-regulated in mature adipocytes and adipocyte tissue of obese individuals.

DISEASE: Congenital short bowel syndrome (CSBS) OMIM: A disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life. caused by mutations affecting the gene represented in this entry.

UniProt features for CLMP_HUMAN » CXADR-like membrane protein
SIGNAL 1 18 Potential.
CHAIN 19 373 CXADR-like membrane protein.
DOMAIN 19 127 Ig-like C2-type 1.
DOMAIN 135 224 Ig-like C2-type 2.
DISULFID 35 111 By similarity.
DISULFID 153 208 By similarity.
Amino Acid Sequence for CLMP_HUMAN » CXADR-like membrane protein
MSLLLLLLLV SYYVGTLGTH TEIKRVAEEK VTLPCHHQLG LPEKDTLDIE WLLTDNEGNQ KVVITYSSRH VYNNLTEEQK GRVAFASNFL AGDASLQIEP LKPSDEGRYT CKVKNSGRYV WSHVILKVLV RPSKPKCELE GELTEGSDLT LQCESSSGTE PIVYYWQRIR EKEGEDERLP PKSRIDYNHP GRVLLQNLTM SYSGLYQCTA GNEAGKESCV VRVTVQYVQS IGMVAGAVTG IVAGALLIFL LVWLLIRRKD KERYEEEERP NEIREDAEAP KARLVKPSSS SSGSRSSRSG SSSTRSTANS ASRSQRTLST DAAPQPGLAT QAYSLVGPEV RGSEPKKVHH ANLTKAETTP SMIPSQSRAF QTV