CLM9_HUMAN » CMRF35-like molecule 9

CLM9_HUMAN » CMRF35-like molecule 9
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLM9_HUMAN » CMRF35-like molecule 9 » CLM-9; CD300 antigen-like family member G;Triggering receptor expressed on myeloid cells 4;TREM-4;
Hydrophobic Thickness 33.6 ± 3.4 Å
Tilt Angle 47 ± 2°
ΔGtransfer -28.3 kcal/mol
ΔGfold -17.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 244-273 (244-278)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 20-119, PDBID: 2Q87, Subunit A, Seq Identity:44%, Immunoglobulin V-set domain

UniProt annotation for CLM9_HUMAN » CMRF35-like molecule 9
FUNCTION: Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and placenta.

DOMAIN: Ig-like V-type domain mediates binding to lymphocyte.

UniProt features for CLM9_HUMAN » CMRF35-like molecule 9
SIGNAL 1 18
CHAIN 19 332 CMRF35-like molecule 9.
DOMAIN 19 121 Ig-like V-type.
DISULFID 37 107 By similarity.
Amino Acid Sequence for CLM9_HUMAN » CMRF35-like molecule 9
MRLLVLLWGC LLLPGYEALE GPEEISGFEG DTVSLQCTYR EELRDHRKYW CRKGGILFSR CSGTIYAEEE GQETMKGRVS IRDSRQELSL IVTLWNLTLQ DAGEYWCGVE KRGPDESLLI SLFVFPGPCC PPSPSPTFQP LATTRLQPKA KAQQTQPPGL TSPGLYPAAT TAKQGKTGAE APPLPGTSQY GHERTSQYTG TSPHPATSPP AGSSRPPMQL DSTSAEDTSP ALSSGSSKPR VSIPMVRILA PVLVLLSLLS AAGLIAFCSH LLLWRKEAQQ ATETQRNEKF WLSRLTAEEK EAPSQAPEGD VISMPPLHTS EEELGFSKFV SA