CLM8_HUMAN » CMRF35-like molecule 8

CLM8_HUMAN » CMRF35-like molecule 8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLM8_HUMAN » CMRF35-like molecule 8 » CLM-8; CD300 antigen-like family member A;CMRF-35-H9;CMRF35-H9; CMRF35-H;IRC1/IRC2;Immunoglobulin superfamily member 12;IgSF12; Inhibitory receptor protein 60;IRp60; NK inhibitory receptor;
Hydrophobic Thickness 35.6 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.6 kcal/mol
ΔGfold -22.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 178-203 (178-205)
Pathways none
PDB 2q87 (A/B/C=19-125)
OPM none
Complexes

CLM8:CLM8_HUMAN

Interactions

CLM8, Complex: Homotrimer of inhibitory protein 60 ectodomain, PDBID: 2Q87

Domains

AA: 20-123, PDBID: 2Q87, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 180-277, SHP2-interacting transmembrane adaptor protein, SIT

UniProt annotation for CLM8_HUMAN » CMRF35-like molecule 8
FUNCTION: Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.

SUBUNIT: Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D.

TISSUE SPECIFICITY: Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.

UniProt features for CLM8_HUMAN » CMRF35-like molecule 8
SIGNAL 1 17 Potential.
CHAIN 18 299 CMRF35-like molecule 8.
DOMAIN 19 123 Ig-like V-type.
DISULFID 36 103 Potential.
Amino Acid Sequence for CLM8_HUMAN » CMRF35-like molecule 8
MWLPWALLLL WVPGCFALSK CRTVAGPVGG SLSVQCPYEK EHRTLNKYWC RPPQIFLCDK IVETKGSAGK RNGRVSIRDS PANLSFTVTL ENLTEEDAGT YWCGVDTPWL RDFHDPVVEV EVSVFPASTS MTPASITAAK TSTITTAFPP VSSTTLFAVG ATHSASIQEE TEEVVNSQLP LLLSLLALLL LLLVGASLLA WRMFQKWIKA GDHSELSQNP KQAATQSELH YANLELLMWP LQEKPAPPRE VEVEYSTVAS PREELHYASV VFDSNTNRIA AQRPREEEPD SDYSVIRKT