CLM7_HUMAN » CMRF35-like molecule 7

CLM7_HUMAN » CMRF35-like molecule 7
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Topology in Plasma membrane
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CLM7_HUMAN » CMRF35-like molecule 7 » CLM-7; CD300 antigen-like family member B;CMRF35-A2;Immune receptor expressed on myeloid cells 3;IREM-3; Leukocyte mono-Ig-like receptor 5;Triggering receptor expressed on myeloid cells 5;TREM-5;
Hydrophobic Thickness 34.8 ± 2.2 Å
Tilt Angle 8 ± 5°
ΔGtransfer -27.5 kcal/mol
ΔGfold -16.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 151-175 (150-176)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:CLM7, PubMed

TYOBP, Complex: CLM7:TYOBP, PubMed

Domains

AA: 19-122, PDBID: 2NMS, Subunit A, Seq Identity:67%, Immunoglobulin V-set domain

UniProt annotation for CLM7_HUMAN » CMRF35-like molecule 7
FUNCTION: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

SUBUNIT: Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.

TISSUE SPECIFICITY: Expressed exclusively in myeloid lineages.

UniProt features for CLM7_HUMAN » CMRF35-like molecule 7
SIGNAL 1 17 Potential.
CHAIN 18 201 CMRF35-like molecule 7.
DOMAIN 18 120 Ig-like V-type.
SITE 158 158 Interaction with TYROBP.
DISULFID 36 104 By similarity.
Amino Acid Sequence for CLM7_HUMAN » CMRF35-like molecule 7
MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC RGVRWDTCKI LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD VYWCGIERRG PDLGTQVKVI VDPEGAASTT ASSPTNSNMA VFIGSHKRNH YMLLVFVKVP ILLILVTAIL WLKGSQRVPE EPGEQPIYMN FSEPLTKDMA T