CLM2_HUMAN » CMRF35-like molecule 2

CLM2_HUMAN » CMRF35-like molecule 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLM2_HUMAN » CMRF35-like molecule 2 » CLM-2; CD300 antigen-like family member E;CMRF35-A5;Immune receptor expressed on myeloid cells 2;IREM-2; Polymeric immunoglobulin receptor 2;PIgR-2; PIgR2; Poly-Ig receptor 2;
Hydrophobic Thickness 32.0 ± 2.0 Å
Tilt Angle 16 ± 2°
ΔGtransfer -23.4 kcal/mol
ΔGfold -11.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 173-196 (171-197)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions

TYOBP, Complex: CLM2:TYOBP, PubMed

Domains

AA: 19-127, PDBID: 1ZOX, Subunit A, Seq Identity:46%, Immunoglobulin V-set domain

UniProt annotation for CLM2_HUMAN » CMRF35-like molecule 2
FUNCTION: Probably acts as an activating receptor.

SUBUNIT: Interacts with TYROBP.

TISSUE SPECIFICITY: Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).

UniProt features for CLM2_HUMAN » CMRF35-like molecule 2
SIGNAL 1 17 Potential.
CHAIN 18 205 CMRF35-like molecule 2.
DOMAIN 18 120 Ig-like V-type.
DISULFID 36 104 By similarity.
Amino Acid Sequence for CLM2_HUMAN » CMRF35-like molecule 2
MWLLPALLLL CLSGCLSLKG PGSVTGTAGD SLTVWCQYES MYKGYNKYWC RGQYDTSCES IVETKGEEKV ERNGRVSIRD HPEALAFTVT MQNLNEDDAG SYWCKIQTVW VLDSWSRDPS DLVRVYVSPA ITTPRRTTHP ATPPIFLVVN PGRNLSTREV LTQNSGFRLS SPHFLLVVLL KLPLLLSMLG AVFWVNRPQW APPGR