CLM1_HUMAN » CMRF35-like molecule 1

CLM1_HUMAN » CMRF35-like molecule 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLM1_HUMAN » CMRF35-like molecule 1 » CLM-1; CD300 antigen-like family member F;Immune receptor expressed on myeloid cells 1;IREM-1; Immunoglobulin superfamily member 13;IgSF13; NK inhibitory receptor;
Hydrophobic Thickness 34.0 ± 5.0 Å
Tilt Angle 40 ± 0°
ΔGtransfer -32.0 kcal/mol
ΔGfold -29.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 151-180 (148-185)
Pathways none
PDB 2nms (21-140)
OPM none
Complexes none
Interactions

A4, Complex: CLM1:A4, PubMed

Domains

AA: 23-126, PDBID: 2NMS, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 157-259, SHP2-interacting transmembrane adaptor protein, SIT

UniProt annotation for CLM1_HUMAN » CMRF35-like molecule 1
FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.

SUBUNIT: Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner.

TISSUE SPECIFICITY: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.

UniProt features for CLM1_HUMAN » CMRF35-like molecule 1
SIGNAL 1 19
CHAIN 20 290 CMRF35-like molecule 1.
DOMAIN 20 126 Ig-like V-type.
SITE 205 205 Phosphatase-binding.
DISULFID 40 108
DISULFID 54 62
Amino Acid Sequence for CLM1_HUMAN » CMRF35-like molecule 1
MPLLTLYLLL FWLSGYSIAT QITGPTTVNG LERGSLTVQC VYRSGWETYL KWWCRGAIWR DCKILVKTSG SEQEVKRDRV SIKDNQKNRT FTVTMEDLMK TDADTYWCGI EKTGNDLGVT VQVTIDPAPV TQEETSSSPT LTGHHLDNRH KLLKLSVLLP LIFTILLLLL VAASLLAWRM MKYQQKAAGM SPEQVLQPLE GDLCYADLTL QLAGTSPRKA TTKLSSAQVD QVEVEYVTMA SLPKEDISYA SLTLGAEDQE PTYCNMGHLS SHLPGRGPEE PTEYSTISRP