CLGN_HUMAN » Calmegin

CLGN_HUMAN » Calmegin
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
CLGN_HUMAN » Calmegin »
Hydrophobic Thickness 30.8 ± 1.4 Å
Tilt Angle 33 ± 4°
ΔGtransfer -18.7 kcal/mol
ΔGfold -10.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 470-493 (470-500)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ADAM2, Complex: CLGN:ADAM2, PubMed

GDE1, Complex: GDE1:CLGN

TLR9, Complex: CLGN:TLR9, PubMed

TLR9, Complex: UGGG1:PALD:TLR9:UN93B:CLGN:S11IP:TRAF3:TOLIP, PubMed

Domains

AA: 62-429, PDBID: 3ICI, Subunit C, Seq Identity:93%, Calreticulin family

UniProt annotation for CLGN_HUMAN » Calmegin
FUNCTION: Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).

SUBUNIT: Interacts with PPIB. Interacts with ADAM2 (By similarity). Interacts with PDILT.

TISSUE SPECIFICITY: Detected in testis (at protein level). Detected in testis.

UniProt features for CLGN_HUMAN » Calmegin
SIGNAL 1 19 Potential.
CHAIN 20 610 Calmegin.
REPEAT 267 280 1-1.
REPEAT 284 297 1-2.
REPEAT 303 316 1-3.
REPEAT 322 335 1-4.
REPEAT 339 352 2-1.
REPEAT 356 369 2-2.
REPEAT 370 383 2-3.
REPEAT 384 397 2-4.
DISULFID 151 185 By similarity.
DISULFID 351 355 By similarity.
Amino Acid Sequence for CLGN_HUMAN » Calmegin
MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK YKTPQPIGEV YFAETFDSGR LAGWVLSKAK KDDMDEEISI YDGRWEIEEL KENQVPGDRG LVLKSRAKHH AISAVLAKPF IFADKPLIVQ YEVNFQDGID CGGAYIKLLA DTDDLILENF YDKTSYIIMF GPDKCGEDYK LHFIFRHKHP KTGVFEEKHA KPPDVDLKKF FTDRKTHLYT LVMNPDDTFE VLVDQTVVNK GSLLEDVVPP IKPPKEIEDP NDKKPEEWDE RAKIPDPSAV KPEDWDESEP AQIEDSSVVK PAGWLDDEPK FIPDPNAEKP DDWNEDTDGE WEAPQILNPA CRIGCGEWKP PMIDNPKYKG VWRPPLVDNP NYQGIWSPRK IPNPDYFEDD HPFLLTSFSA LGLELWSMTS DIYFDNFIIC SEKEVADHWA ADGWRWKIMI ANANKPGVLK QLMAAAEGHP WLWLIYLVTA GVPIALITSF CWPRKVKKKH KDTEYKKTDI CIPQTKGVLE QEEKEEKAAL EKPMDLEEEK KQNDGEMLEK EEESEPEEKS EEEIEIIEGQ EESNQSNKSG SEDEMKEADE STGSGDGPIK SVRKRRVRKD