CLCL1_HUMAN » C-type lectin-like domain family 1

CLCL1_HUMAN » C-type lectin-like domain family 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLCL1_HUMAN » C-type lectin-like domain family 1 » Dendritic cell-associated lectin 1;DC-associated lectin-1; DCAL-1;
Hydrophobic Thickness 34.4 ± 2.4 Å
Tilt Angle 9 ± 6°
ΔGtransfer -23.2 kcal/mol
ΔGfold -10.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 63-88 (63-89)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for CLCL1_HUMAN » C-type lectin-like domain family 1
FUNCTION: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

TISSUE SPECIFICITY: Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells.

UniProt features for CLCL1_HUMAN » C-type lectin-like domain family 1
CHAIN 1 167 C-type lectin-like domain family 1.
DOMAIN 116 167 C-type lectin; atypical.
Amino Acid Sequence for CLCL1_HUMAN » C-type lectin-like domain family 1
MVSNFFHVIQ VFEKSATLIS KTEHIGFVIY SWRKSTTHLG SRRKFAISIY LSEVSLQKYD CPFSGTSFVV FSLFLICAMA GDVVYADIKT VRTSPLELAF PLQRSVSFNF STVHKSCPAK DWKVHKGKCY WIAETKKSWN KSQNDCAINN SYLMVIQDIT AMVRFNI