CLC9A_HUMAN » C-type lectin domain family 9 member A

CLC9A_HUMAN » C-type lectin domain family 9 member A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC9A_HUMAN » C-type lectin domain family 9 member A »
Hydrophobic Thickness 42.4 ± 1.0 Å
Tilt Angle 0 ± 1°
ΔGtransfer -45.0 kcal/mol
ΔGfold -12.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 29-59 (25-59)
Pathways none
PDB 3vpp (110-241)
OPM none
Complexes none
Interactions none
Domains

AA: 131-234, PDBID: 3VPP, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC9A_HUMAN » C-type lectin domain family 9 member A
FUNCTION: Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.

UniProt features for CLC9A_HUMAN » C-type lectin domain family 9 member A
CHAIN 1 241 C-type lectin domain family 9 member A.
DOMAIN 120 233 C-type lectin.
MOTIF 5 10 ITAM-like.
DISULFID 113 124
DISULFID 141 232
DISULFID 211 224
Amino Acid Sequence for CLC9A_HUMAN » C-type lectin domain family 9 member A
MHEEEIYTSL QWDSPAPDTY QKCLSSNKCS GACCLVMVIS CVFCMGLLTA SIFLGVKLLQ VSTIAMQQQE KLIQQERALL NFTEWKRSCA LQMKYCQAFM QNSLSSAHNS SPCPNNWIQN RESCYYVSEI WSIWHTSQEN CLKEGSTLLQ IESKEEMDFI TGSLRKIKGS YDYWVGLSQD GHSGRWLWQD GSSPSPGLLP AERSQSANQV CGYVKSNSLL SSNCSTWKYF ICEKYALRSS V