CLC7A_HUMAN » C-type lectin domain family 7 member A

CLC7A_HUMAN » C-type lectin domain family 7 member A
Magnify CLC7A_HUMAN » C-type lectin domain family 7 member AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC7A_HUMAN » C-type lectin domain family 7 member A » Beta-glucan receptor;C-type lectin superfamily member 12;Dendritic cell-associated C-type lectin 1;DC-associated C-type lectin 1; Dectin-1;
Hydrophobic Thickness 35.2 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -51.2 kcal/mol
ΔGfold -27.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 41-69 (41-74)
Pathways

Phagosome (KEGG)

Tuberculosis (KEGG)

PDB none
OPM none
Complexes

CLC7A:CLC7A_MOUSE

Interactions

ADA33, Complex: CLC7A:ADA33

BNI3L, Complex: BNI3L:CLC7A

BNIP3, Complex: BNIP3:CLC7A

CLC7A, Complex: Homodimer of C-type lectin domain 7A, PDBID: 2BPD

ILRL1, Complex: ILRL1:CLC7A

KTN1, Complex: KTN1:CLC7A

PTTG, Complex: PTTG:CLC7A

SMIM3, Complex: SMIM3:CLC7A

SYNE4, Complex: SYNE4:CLC7A

TLR2, Complex: TLR2:CLC7A, PubMed

TMPS4, Complex: CLC7A:TMPS4

Domains

AA: 137-243, PDBID: 2BPD, Subunit B, Seq Identity:61%, Lectin C-type domain

UniProt annotation for CLC7A_HUMAN » C-type lectin domain family 7 member A
FUNCTION: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).

SUBUNIT: Homodimer (By similarity). Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens (By similarity). Isoform 5 interacts with RANBP9.

TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.

INDUCTION: Up-regulated during differentiation from monocytes into dendritic cells.

DISEASE: Candidiasis, familial, 4 (CANDF4) OMIM: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. mutations affecting the gene represented in this entry.

UniProt features for CLC7A_HUMAN » C-type lectin domain family 7 member A
CHAIN 1 247 C-type lectin domain family 7 member A.
DOMAIN 127 242 C-type lectin.
MOTIF 15 18 ITAM-like.
DISULFID 120 131 By similarity.
DISULFID 148 241 By similarity.
DISULFID 220 233 By similarity.
Amino Acid Sequence for CLC7A_HUMAN » C-type lectin domain family 7 member A
MEYHPDLENL DEDGYTQLHF DSQSNTRIAV VSEKGSCAAS PPWRLIAVIL GILCLVILVI AVVLGTMAIW RSNSGSNTLE NGYFLSRNKE NHSQPTQSSL EDSVTPTKAV KTTGVLSSPC PPNWIIYEKS CYLFSMSLNS WDGSKRQCWQ LGSNLLKIDS SNELGFIVKQ VSSQPDNSFW IGLSRPQTEV PWLWEDGSTF SSNLFQIRTT ATQENPSPNC VWIHVSVIYD QLCSVPSYSI CEKKFSM