|CLC7A_HUMAN » C-type lectin domain family 7 member A » Beta-glucan receptor;C-type lectin superfamily member 12;Dendritic cell-associated C-type lectin 1;DC-associated C-type lectin 1; Dectin-1;|
|Hydrophobic Thickness||35.2 ± 2.0 Å|
|Tilt Angle||0 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||41-69 (41-74)|
ADA33, Complex: CLC7A:ADA33
BNI3L, Complex: BNI3L:CLC7A
BNIP3, Complex: BNIP3:CLC7A
ILRL1, Complex: ILRL1:CLC7A
KTN1, Complex: KTN1:CLC7A
PTTG, Complex: PTTG:CLC7A
SMIM3, Complex: SMIM3:CLC7A
SYNE4, Complex: SYNE4:CLC7A
TMPS4, Complex: CLC7A:TMPS4
|UniProt annotation for CLC7A_HUMAN » C-type lectin domain family 7 member A|
|FUNCTION: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). SUBUNIT: Homodimer (By similarity). Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens (By similarity). Isoform 5 interacts with RANBP9. TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. INDUCTION: Up-regulated during differentiation from monocytes into dendritic cells. DISEASE: Candidiasis, familial, 4 (CANDF4) OMIM: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. mutations affecting the gene represented in this entry.|
|UniProt features for CLC7A_HUMAN » C-type lectin domain family 7 member A|
CHAIN 1 247 C-type lectin domain family 7 member A. |
DOMAIN 127 242 C-type lectin.
MOTIF 15 18 ITAM-like.
DISULFID 120 131 By similarity.
DISULFID 148 241 By similarity.
DISULFID 220 233 By similarity.
|Amino Acid Sequence for CLC7A_HUMAN » C-type lectin domain family 7 member A|
|MEYHPDLENL DEDGYTQLHF DSQSNTRIAV VSEKGSCAAS PPWRLIAVIL GILCLVILVI AVVLGTMAIW RSNSGSNTLE NGYFLSRNKE NHSQPTQSSL EDSVTPTKAV KTTGVLSSPC PPNWIIYEKS CYLFSMSLNS WDGSKRQCWQ LGSNLLKIDS SNELGFIVKQ VSSQPDNSFW IGLSRPQTEV PWLWEDGSTF SSNLFQIRTT ATQENPSPNC VWIHVSVIYD QLCSVPSYSI CEKKFSM|