CLC6A_HUMAN » C-type lectin domain family 6 member A

CLC6A_HUMAN » C-type lectin domain family 6 member A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC6A_HUMAN » C-type lectin domain family 6 member A » C-type lectin superfamily member 10;Dendritic cell-associated C-type lectin 2;DC-associated C-type lectin 2; Dectin-2;
Hydrophobic Thickness 42.8 ± 0.4 Å
Tilt Angle 4 ± 4°
ΔGtransfer -46.9 kcal/mol
ΔGfold -15.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 20-46 (15-47)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CLC4D, Complex: CLC4D:CLC6A, PubMed

Domains

AA: 96-204, PDBID: 3WBP, Subunit B, Seq Identity:53%, Lectin C-type domain

UniProt annotation for CLC6A_HUMAN » C-type lectin domain family 6 member A
FUNCTION: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity).

SUBUNIT: Associated with FCER1G.

TISSUE SPECIFICITY: Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.

INDUCTION: Up-regulated by granulocyte-macrophage colony- stimulating factor (GM-CSF), TGF-beta 1, TNF-alpha and down- regulated by IL-4, IL-10 or UVB in CD14+ monocytes.

DOMAIN: A short stretch of the intracellular domain (AA 8-14) proximal to the transmembrane domain is required for association with Fc receptor gamma chain.

UniProt features for CLC6A_HUMAN » C-type lectin domain family 6 member A
CHAIN 1 209 C-type lectin domain family 6 member A.
DOMAIN 86 203 C-type lectin.
DISULFID 79 90 By similarity.
DISULFID 107 202 By similarity.
DISULFID 176 194 By similarity.
Amino Acid Sequence for CLC6A_HUMAN » C-type lectin domain family 6 member A
MMQEQQPQST EKRGWLSLRL WSVAGISIAL LSACFIVSCV VTYHFTYGET GKRLSELHSY HSSLTCFSEG TKVPAWGCCP ASWKSFGSSC YFISSEEKVW SKSEQNCVEM GAHLVVFNTE AEQNFIVQQL NESFSYFLGL SDPQGNNNWQ WIDKTPYEKN VRFWHLGEPN HSAEQCASIV FWKPTGWGWN DVICETRRNS ICEMNKIYL