|CLC5A_HUMAN » C-type lectin domain family 5 member A » C-type lectin superfamily member 5;Myeloid DAP12-associating lectin 1;MDL-1;|
|Hydrophobic Thickness||34.4 ± 1.4 Å|
|Tilt Angle||0 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB|
|TM Segments||3-31 (3-34)|
Immune System (Reactome)
|UniProt annotation for CLC5A_HUMAN » C-type lectin domain family 5 member A|
|FUNCTION: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. SUBUNIT: Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP. TISSUE SPECIFICITY: Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.|
|UniProt features for CLC5A_HUMAN » C-type lectin domain family 5 member A|
CHAIN 1 188 C-type lectin domain family 5 member A. |
DOMAIN 78 184 C-type lectin.
DISULFID 71 82 By similarity.
DISULFID 99 183 By similarity.
DISULFID 161 175 By similarity.
|Amino Acid Sequence for CLC5A_HUMAN » C-type lectin domain family 5 member A|
|MNWHMIISGL IVVVLKVVGM TLFLLYFPQI FNKSNDGFTT TRSYGTVSQI FGSSSPSPNG FITTRSYGTV CPKDWEFYQA RCFFLSTSES SWNESRDFCK GKGSTLAIVN TPEKLKFLQD ITDAEKYFIG LIYHREEKRW RWINNSVFNG NVTNQNQNFN CATIGLTKTF DAASCDISYR RICEKNAK|