CLC5A_HUMAN » C-type lectin domain family 5 member A

CLC5A_HUMAN » C-type lectin domain family 5 member A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC5A_HUMAN » C-type lectin domain family 5 member A » C-type lectin superfamily member 5;Myeloid DAP12-associating lectin 1;MDL-1;
Hydrophobic Thickness 34.4 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -38.8 kcal/mol
ΔGfold -14.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 3-31 (3-34)
Pathways

Immune System (Reactome)

PDB 2yhf (70-187)
OPM none
Complexes none
Interactions

TYOBP, Complex: CLC5A:TYOBP, PubMed

Domains

AA: 88-185, PDBID: 2YHF, Subunit C, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC5A_HUMAN » C-type lectin domain family 5 member A
FUNCTION: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

SUBUNIT: Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.

TISSUE SPECIFICITY: Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.

UniProt features for CLC5A_HUMAN » C-type lectin domain family 5 member A
CHAIN 1 188 C-type lectin domain family 5 member A.
DOMAIN 78 184 C-type lectin.
DISULFID 71 82 By similarity.
DISULFID 99 183 By similarity.
DISULFID 161 175 By similarity.
Amino Acid Sequence for CLC5A_HUMAN » C-type lectin domain family 5 member A
MNWHMIISGL IVVVLKVVGM TLFLLYFPQI FNKSNDGFTT TRSYGTVSQI FGSSSPSPNG FITTRSYGTV CPKDWEFYQA RCFFLSTSES SWNESRDFCK GKGSTLAIVN TPEKLKFLQD ITDAEKYFIG LIYHREEKRW RWINNSVFNG NVTNQNQNFN CATIGLTKTF DAASCDISYR RICEKNAK