CLC4M_HUMAN » C-type lectin domain family 4 member M

CLC4M_HUMAN » C-type lectin domain family 4 member M
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC4M_HUMAN » C-type lectin domain family 4 member M » CD209 antigen-like protein 1;DC-SIGN-related protein;DC-SIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2;DC-SIGN2; Liver/lymph node-specific ICAM-3-grabbing non-integrin;L-SIGN;
Hydrophobic Thickness 30.8 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -41.5 kcal/mol
ΔGfold -18.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 51-75 (48-75)
Pathways

Measles (KEGG)

Phagosome (KEGG)

Tuberculosis (KEGG)

PDB 1sl6 (216-399), 1xph (250-399), 1xar (A/B=216-399), 1k9j (A/B=262-399), 3jqh (A=101-264)
OPM none
Complexes

CLC4M:CLC4M_HUMAN

Interactions

CD209, Complex: CLC4M:CD209, PubMed

CEAM1, Complex: CEAM1:CLC4M, PubMed

CLC4M, Complex: Homodimer of C-type lectin domain 4M, PDBID: 1K9J

ICAM3, Complex: CLC4M:ICAM3, PubMed

ITAM, Complex: CLC4M:ITAM, PubMed

NEP, Complex: CLC4M:NEP, PubMed

TLR2, Complex: CLC4M:TLR2, PubMed

Domains

AA: 285-391, PDBID: 1K9J, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC4M_HUMAN » C-type lectin domain family 4 member M
FUNCTION: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.

SUBUNIT: Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus S protein.

TISSUE SPECIFICITY: Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.

DOMAIN: The tandem repeat domain, also called neck domain, mediates oligomerization.

MISCELLANEOUS: In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells.

UniProt features for CLC4M_HUMAN » C-type lectin domain family 4 member M
CHAIN 1 399 C-type lectin domain family 4 member M.
REPEAT 108 130 1.
REPEAT 131 153 2.
REPEAT 154 176 3.
REPEAT 177 199 4.
REPEAT 200 222 5.
REPEAT 223 245 6.
REPEAT 246 268 7.
DOMAIN 274 390 C-type lectin.
REGION 108 269 7 X approximate tandem repeats.
MOTIF 14 15 Endocytosis signal (By similarity).
DISULFID 265 395
DISULFID 268 279
DISULFID 296 389
DISULFID 368 381
Amino Acid Sequence for CLC4M_HUMAN » C-type lectin domain family 4 member M
MSDSKEPRVQ QLGLLEEDPT TSGIRLFPRD FQFQQIHGHK SSTGCLGHGA LVLQLLSFML LAGVLVAILV QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE