CLC4K_HUMAN » C-type lectin domain family 4 member K

CLC4K_HUMAN » C-type lectin domain family 4 member K
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC4K_HUMAN » C-type lectin domain family 4 member K » Langerin;
Hydrophobic Thickness 35.2 ± 3.0 Å
Tilt Angle 18 ± 17°
ΔGtransfer -22.7 kcal/mol
ΔGfold -14.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 41-64 (40-64)
Pathways

Immune System (Reactome)

PDB 3c22 (188-328), 3p5d (193-328), 3p5e (193-328), 3p5f (193-328), 3p5g (193-328), 3p5h (193-328), 3p5i (193-328), 3p7f (193-328), 3p7g (193-328), 3p7h (193-328), 3kqg (A/B...=147-328), 4ak8 (A/B/C/D=188-328), 4n32 (A/B/C/D=193-328), 4n33 (A/B/C/D=193-328), 4n34 (A/B/C/D=193-328), 4n35 (A/B/C/D=193-328), 4n36 (A/B/C/D=193-328), 4n37 (A/B/C/D=193-328), 4n38 (A/B/C/D=193-328)
OPM none
Complexes

CLC4K:CLC4K_HUMAN

Interactions

CLC4K, Complex: Homotetramer of C-type lectin domain 4K, PDBID: 4AK8

Domains

AA: 212-321, PDBID: 3C22, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC4K_HUMAN » C-type lectin domain family 4 member K
FUNCTION: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

SUBUNIT: Homotrimer.

TISSUE SPECIFICITY: Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.

DOMAIN: The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.

DISEASE: Birbeck granule deficiency (BIRGD) OMIM: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity. mutations affecting the gene represented in this entry.

UniProt features for CLC4K_HUMAN » C-type lectin domain family 4 member K
CHAIN 1 328 C-type lectin domain family 4 member K.
DOMAIN 202 320 C-type lectin.
COILED 145 190 Potential.
DISULFID 223 319
DISULFID 295 311
Amino Acid Sequence for CLC4K_HUMAN » C-type lectin domain family 4 member K
MTVEKEAPDA HFTVDKQNIS LWPREPPPKS GPSLVPGKTP TVRAALICLT LVLVASVLLQ AVLYPRFMGT ISDVKTNVQL LKGRVDNIST LDSEIKKNSD GMEAAGVQIQ MVNESLGYVR SQFLKLKTSV EKANAQIQIL TRSWEEVSTL NAQIPELKSD LEKASALNTK IRALQGSLEN MSKLLKRQND ILQVVSQGWK YFKGNFYYFS LIPKTWYSAE QFCVSRNSHL TSVTSESEQE FLYKTAGGLI YWIGLTKAGM EGDWSWVDDT PFNKVQSVRF WIPGEPNNAG NNEHCGNIKA PSLQAWNDAP CDKTFLFICK RPYVPSEP