CLC4E_HUMAN » C-type lectin domain family 4 member E

CLC4E_HUMAN » C-type lectin domain family 4 member E
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC4E_HUMAN » C-type lectin domain family 4 member E » C-type lectin superfamily member 9;Macrophage-inducible C-type lectin;
Hydrophobic Thickness 29.2 ± 2.4 Å
Tilt Angle 1 ± 4°
ΔGtransfer -39.1 kcal/mol
ΔGfold -12.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 20-42 (18-42)
Pathways

Tuberculosis (KEGG)

PDB 3wh2 (74-219), 3wh3 (74-219)
OPM none
Complexes none
Interactions none
Domains

AA: 97-207, PDBID: 3WH2, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC4E_HUMAN » C-type lectin domain family 4 member E
FUNCTION: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6"-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

SUBUNIT: Monomer. Homodimer.

UniProt features for CLC4E_HUMAN » C-type lectin domain family 4 member E
CHAIN 1 219 C-type lectin domain family 4 member E.
DOMAIN 87 206 C-type lectin.
DISULFID 80 91 By similarity.
DISULFID 108 205 By similarity.
DISULFID 179 197 By similarity.
Amino Acid Sequence for CLC4E_HUMAN » C-type lectin domain family 4 member E
MNSSKSSETQ CTERGCFSSQ MFLWTVAGIP ILFLSACFIT RCVVTFRIFQ TCDEKKFQLP ENFTELSCYN YGSGSVKNCC PLNWEYFQSS CYFFSTDTIS WALSLKNCSA MGAHLVVINS QEEQEFLSYK KPKMREFFIG LSDQVVEGQW QWVDGTPLTK SLSFWDVGEP NNIATLEDCA TMRDSSNPRQ NWNDVTCFLN YFRICEMVGI NPLNKGKSL