|CLC4E_HUMAN » C-type lectin domain family 4 member E » C-type lectin superfamily member 9;Macrophage-inducible C-type lectin;|
|Hydrophobic Thickness||29.2 ± 2.4 Å|
|Tilt Angle||1 ± 4°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||20-42 (18-42)|
|PDB||3wh2 (74-219), 3wh3 (74-219)|
|UniProt annotation for CLC4E_HUMAN » C-type lectin domain family 4 member E|
|FUNCTION: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6"-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. SUBUNIT: Monomer. Homodimer.|
|UniProt features for CLC4E_HUMAN » C-type lectin domain family 4 member E|
CHAIN 1 219 C-type lectin domain family 4 member E. |
DOMAIN 87 206 C-type lectin.
DISULFID 80 91 By similarity.
DISULFID 108 205 By similarity.
DISULFID 179 197 By similarity.
|Amino Acid Sequence for CLC4E_HUMAN » C-type lectin domain family 4 member E|
|MNSSKSSETQ CTERGCFSSQ MFLWTVAGIP ILFLSACFIT RCVVTFRIFQ TCDEKKFQLP ENFTELSCYN YGSGSVKNCC PLNWEYFQSS CYFFSTDTIS WALSLKNCSA MGAHLVVINS QEEQEFLSYK KPKMREFFIG LSDQVVEGQW QWVDGTPLTK SLSFWDVGEP NNIATLEDCA TMRDSSNPRQ NWNDVTCFLN YFRICEMVGI NPLNKGKSL|