|CLC4D_HUMAN » C-type lectin domain family 4 member D » C-type lectin superfamily member 8;C-type lectin-like receptor 6;CLEC-6;|
|Hydrophobic Thickness||34.4 ± 1.8 Å|
|Tilt Angle||0 ± 2°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||18-42 (18-44)|
|PDB||2ls8 (84-215), 3whd (A/C=61-215)|
|UniProt annotation for CLC4D_HUMAN » C-type lectin domain family 4 member D|
|FUNCTION: Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. TISSUE SPECIFICITY: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. INDUCTION: By autocrine inflammatory stimuli.|
|UniProt features for CLC4D_HUMAN » C-type lectin domain family 4 member D|
CHAIN 1 215 C-type lectin domain family 4 member D. |
DOMAIN 91 208 C-type lectin.
DISULFID 84 95 By similarity.
DISULFID 112 207 By similarity.
DISULFID 182 199 By similarity.
|Amino Acid Sequence for CLC4D_HUMAN » C-type lectin domain family 4 member D|
|MGLEKPQSKL EGGMHPQLIP SVIAVVFILL LSVCFIASCL VTHHNFSRCK RGTGVHKLEH HAKLKCIKEK SELKSAEGST WNCCPIDWRA FQSNCYFPLT DNKTWAESER NCSGMGAHLM TISTEAEQNF IIQFLDRRLS YFLGLRDENA KGQWRWVDQT PFNPRRVFWH KNEPDNSQGE NCVVLVYNQD KWAWNDVPCN FEASRICKIP GTTLN|