CLC4D_HUMAN » C-type lectin domain family 4 member D

CLC4D_HUMAN » C-type lectin domain family 4 member D
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC4D_HUMAN » C-type lectin domain family 4 member D » C-type lectin superfamily member 8;C-type lectin-like receptor 6;CLEC-6;
Hydrophobic Thickness 34.4 ± 1.8 Å
Tilt Angle 0 ± 2°
ΔGtransfer -41.1 kcal/mol
ΔGfold -17.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 18-42 (18-44)
Pathways none
PDB 2ls8 (84-215), 3whd (A/C=61-215)
OPM none
Complexes

CLC4D:CLC4D_HUMAN

Interactions

CLC4D, Complex: Homodimer of C-type lectin domain 4D, PDBID: 3WHD

CLC6A, Complex: CLC4D:CLC6A, PubMed

Domains

AA: 101-209, PDBID: 2LS8, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC4D_HUMAN » C-type lectin domain family 4 member D
FUNCTION: Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.

TISSUE SPECIFICITY: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.

INDUCTION: By autocrine inflammatory stimuli.

UniProt features for CLC4D_HUMAN » C-type lectin domain family 4 member D
CHAIN 1 215 C-type lectin domain family 4 member D.
DOMAIN 91 208 C-type lectin.
DISULFID 84 95 By similarity.
DISULFID 112 207 By similarity.
DISULFID 182 199 By similarity.
Amino Acid Sequence for CLC4D_HUMAN » C-type lectin domain family 4 member D
MGLEKPQSKL EGGMHPQLIP SVIAVVFILL LSVCFIASCL VTHHNFSRCK RGTGVHKLEH HAKLKCIKEK SELKSAEGST WNCCPIDWRA FQSNCYFPLT DNKTWAESER NCSGMGAHLM TISTEAEQNF IIQFLDRRLS YFLGLRDENA KGQWRWVDQT PFNPRRVFWH KNEPDNSQGE NCVVLVYNQD KWAWNDVPCN FEASRICKIP GTTLN