|CLC4C_HUMAN » C-type lectin domain family 4 member C » Blood dendritic cell antigen 2;BDCA-2; C-type lectin superfamily member 7;Dendritic lectin;|
|Hydrophobic Thickness||29.6 ± 1.6 Å|
|Tilt Angle||1 ± 4°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB|
|TM Segments||16-40 (16-41)|
|PDB||3wbr (A/B...=83-210), 3wbp (A/B=83-210), 3wbq (A/B=83-210)|
|UniProt annotation for CLC4C_HUMAN » C-type lectin domain family 4 member C|
|FUNCTION: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. TISSUE SPECIFICITY: Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.|
|UniProt features for CLC4C_HUMAN » C-type lectin domain family 4 member C|
CHAIN 1 213 C-type lectin domain family 4 member C. |
DOMAIN 90 207 C-type lectin.
DISULFID 83 94 By similarity.
DISULFID 111 206 By similarity.
DISULFID 180 198 By similarity.
|Amino Acid Sequence for CLC4C_HUMAN » C-type lectin domain family 4 member C|
|MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR RHWQWVDQTP YNENVTFWHS GEPNNLDERC AIINFRSSEE WGWNDIHCHV PQKSICKMKK IYI|