CLC4C_HUMAN » C-type lectin domain family 4 member C

CLC4C_HUMAN » C-type lectin domain family 4 member C
Magnify CLC4C_HUMAN » C-type lectin domain family 4 member CEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC4C_HUMAN » C-type lectin domain family 4 member C » Blood dendritic cell antigen 2;BDCA-2; C-type lectin superfamily member 7;Dendritic lectin;
Hydrophobic Thickness 29.6 ± 1.6 Å
Tilt Angle 1 ± 4°
ΔGtransfer -36.8 kcal/mol
ΔGfold -12.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 16-40 (16-41)
Pathways none
PDB 3wbr (A/B...=83-210), 3wbp (A/B=83-210), 3wbq (A/B=83-210)
OPM none
Complexes

CLC4C:CLC4C_HUMAN

Interactions

CLC4C, Complex: Homodimer of C-type lectin domain 4C, PDBID: 3WBP

FCERG, Complex: CLC4C:FCERG, PubMed

Domains

AA: 101-208, PDBID: 3WBP, Subunit B, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC4C_HUMAN » C-type lectin domain family 4 member C
FUNCTION: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.

TISSUE SPECIFICITY: Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.

UniProt features for CLC4C_HUMAN » C-type lectin domain family 4 member C
CHAIN 1 213 C-type lectin domain family 4 member C.
DOMAIN 90 207 C-type lectin.
DISULFID 83 94 By similarity.
DISULFID 111 206 By similarity.
DISULFID 180 198 By similarity.
Amino Acid Sequence for CLC4C_HUMAN » C-type lectin domain family 4 member C
MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR RHWQWVDQTP YNENVTFWHS GEPNNLDERC AIINFRSSEE WGWNDIHCHV PQKSICKMKK IYI