CLC4A_HUMAN » C-type lectin domain family 4 member A

CLC4A_HUMAN » C-type lectin domain family 4 member A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC4A_HUMAN » C-type lectin domain family 4 member A » C-type lectin DDB27;C-type lectin superfamily member 6;Dendritic cell immunoreceptor;Lectin-like immunoreceptor;
Hydrophobic Thickness 34.0 ± 4.4 Å
Tilt Angle 43 ± 0°
ΔGtransfer -36.5 kcal/mol
ΔGfold -31.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 43-72 (43-79)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 123-232, PDBID: 3WBP, Subunit B, Seq Identity:57%, Lectin C-type domain

UniProt annotation for CLC4A_HUMAN » C-type lectin domain family 4 member A
FUNCTION: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.

SUBUNIT: May interact with PTPN6 via its ITIM motif.

TISSUE SPECIFICITY: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha).

INDUCTION: Isoform 2 mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3, IL4/interleukin-4 and IL13/interleukin-13.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for CLC4A_HUMAN » C-type lectin domain family 4 member A
CHAIN 1 237 C-type lectin domain family 4 member A.
DOMAIN 113 231 C-type lectin.
MOTIF 5 10 ITIM motif.
DISULFID 106 117 By similarity.
DISULFID 134 230 By similarity.
DISULFID 203 222 By similarity.
Amino Acid Sequence for CLC4A_HUMAN » C-type lectin domain family 4 member A
MTSEITYAEV RFKNEFKSSG INTASSAASK ERTAPHKSNT GFPKLLCASL LIFFLLLAIS FFIAFVIFFQ KYSQLLEKKT TKELVHTTLE CVKKNMPVEE TAWSCCPKNW KSFSSNCYFI STESASWQDS EKDCARMEAH LLVINTQEEQ DFIFQNLQEE SAYFVGLSDP EGQRHWQWVD QTPYNESSTF WHPREPSDPN ERCVVLNFRK SPKRWGWNDV NCLGPQRSVC EMMKIHL