CLC2D_HUMAN » C-type lectin domain family 2 member D

CLC2D_HUMAN » C-type lectin domain family 2 member D
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC2D_HUMAN » C-type lectin domain family 2 member D » Lectin-like NK cell receptor;Lectin-like transcript 1;LLT-1; Osteoclast inhibitory lectin;
Hydrophobic Thickness 41.2 ± 1.6 Å
Tilt Angle 3 ± 1°
ΔGtransfer -46.3 kcal/mol
ΔGfold -25.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 31-59 (27-62)
Pathways none
PDB 4qkg (72-191), 4qkh (A/B=72-191), 4qki (A/B=72-191), 4qkj (A=72-191)
OPM none
Complexes

CLC2D:CLC2D_HUMAN

Interactions

CLC2D, Complex: Homodimer of C-type lectin domain 2D, PDBID: 4QKH

KLRB1, Complex: CLC2D:KLRB1, PubMed

Domains

AA: 92-186, PDBID: 4QKG, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC2D_HUMAN » C-type lectin domain family 2 member D
FUNCTION: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.

SUBUNIT: Homodimer or heterodimer; disulfide-linked.

TISSUE SPECIFICITY: Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.

INDUCTION: Up-regulated by IL1A/interleukin-1 alpha and prostaglandin E2 in cultured osteogenic sarcoma cells.

UniProt features for CLC2D_HUMAN » C-type lectin domain family 2 member D
CHAIN 1 191 C-type lectin domain family 2 member D.
DOMAIN 82 185 C-type lectin.
DISULFID 75 86 By similarity.
DISULFID 103 184 By similarity.
Amino Acid Sequence for CLC2D_HUMAN » C-type lectin domain family 2 member D
MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQFPILGA GECAYLNDKG ASSARHYTER KWICSKSDIH V