|CLC2A_HUMAN » C-type lectin domain family 2 member A » Keratinocyte-associated C-type lectin;KACL; Proliferation-induced lymphocyte-associated receptor;PILAR;|
|Hydrophobic Thickness||33.6 ± 2.2 Å|
|Tilt Angle||0 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||26-51 (23-53)|
|UniProt annotation for CLC2A_HUMAN » C-type lectin domain family 2 member A|
|FUNCTION: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. SUBUNIT: Homodimer; non disulfide-linked. Interacts with KLRB1. Interacts with KLRF2. TISSUE SPECIFICITY: Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells. INDUCTION: By phytohemagglutinin (PHA) in peripheral CD8(+) T cells.|
|UniProt features for CLC2A_HUMAN » C-type lectin domain family 2 member A|
CHAIN 1 174 C-type lectin domain family 2 member A. |
DOMAIN 65 174 C-type lectin.
DISULFID 58 69 By similarity.
DISULFID 86 167 By similarity.
|Amino Acid Sequence for CLC2A_HUMAN » C-type lectin domain family 2 member A|
|MINPELRDGR ADGFIHRIVP KLIQNWKIGL MCFLSIIITT VCIIMIATWS KHAKPVACSG DWLGVRDKCF YFSDDTRNWT ASKIFCSLQK AELAQIDTQE DMEFLKRYAG TDMHWIGLSR KQGDSWKWTN GTTFNGWFEI IGNGSFAFLS ADGVHSSRGF IDIKWICSKP KYFL|