CLC2A_HUMAN » C-type lectin domain family 2 member A

CLC2A_HUMAN » C-type lectin domain family 2 member A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC2A_HUMAN » C-type lectin domain family 2 member A » Keratinocyte-associated C-type lectin;KACL; Proliferation-induced lymphocyte-associated receptor;PILAR;
Hydrophobic Thickness 33.6 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -42.0 kcal/mol
ΔGfold -18.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 26-51 (23-53)
Pathways none
PDB 4iop (A=46-174)
OPM none
Complexes

KLRF2:CLC2A_HUMAN

Interactions

KLRF2, Complex: CLC2A:KLRF2, PDBID: 4IOP, PubMed

Domains

AA: 75-156, PDBID: 4IOP, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC2A_HUMAN » C-type lectin domain family 2 member A
FUNCTION: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.

SUBUNIT: Homodimer; non disulfide-linked. Interacts with KLRB1. Interacts with KLRF2.

TISSUE SPECIFICITY: Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.

INDUCTION: By phytohemagglutinin (PHA) in peripheral CD8(+) T cells.

UniProt features for CLC2A_HUMAN » C-type lectin domain family 2 member A
CHAIN 1 174 C-type lectin domain family 2 member A.
DOMAIN 65 174 C-type lectin.
DISULFID 58 69 By similarity.
DISULFID 86 167 By similarity.
Amino Acid Sequence for CLC2A_HUMAN » C-type lectin domain family 2 member A
MINPELRDGR ADGFIHRIVP KLIQNWKIGL MCFLSIIITT VCIIMIATWS KHAKPVACSG DWLGVRDKCF YFSDDTRNWT ASKIFCSLQK AELAQIDTQE DMEFLKRYAG TDMHWIGLSR KQGDSWKWTN GTTFNGWFEI IGNGSFAFLS ADGVHSSRGF IDIKWICSKP KYFL