CLC1B_HUMAN » C-type lectin domain family 1 member B

CLC1B_HUMAN » C-type lectin domain family 1 member B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC1B_HUMAN » C-type lectin domain family 1 member B » C-type lectin-like receptor 2;CLEC-2;
Hydrophobic Thickness 41.2 ± 1.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -55.2 kcal/mol
ΔGfold -24.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 28-57 (25-59)
Pathways none
PDB 2c6u (100-221), 3wsr (A/B=96-221), 3wwk (C/F/I/L=96-221)
OPM none
Complexes

PDPN:CLC1B_HUMAN

Interactions

PDPN, Complex: PDPN:CLC1B, PDBID: 3WSR

Domains

AA: 119-218, PDBID: 2C6U, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CLC1B_HUMAN » C-type lectin domain family 1 member B
SUBUNIT: Homodimer. Interacts (via cytoplasmic domain) with GNB2L1/RACK1; promotes CLEC1B ubiquitination and proteasome- mediated degradation. Interacts (dimer) with SYK (via SH2 domains).

TISSUE SPECIFICITY: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.

MISCELLANEOUS: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2 (PubMed). Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed).

UniProt features for CLC1B_HUMAN » C-type lectin domain family 1 member B
CHAIN 1 229 C-type lectin domain family 1 member B.
DOMAIN 109 217 C-type lectin.
DISULFID 102 113
DISULFID 130 216
DISULFID 195 208
Amino Acid Sequence for CLC1B_HUMAN » C-type lectin domain family 1 member B
MQDEDGYITL NIKTRKPALI SVGSASSSWW RVMALILLIL CVGMVVGLVA LGIWSVMQRN YLQGENENRT GTLQQLAKRF CQYVVKQSEL KGTFKGHKCS PCDTNWRYYG DSCYGFFRHN LTWEESKQYC TDMNATLLKI DNRNIVEYIK ARTHLIRWVG LSRQKSNEVW KWEDGSVISE NMFEFLEDGK GNMNCAYFHN GKMHPTFCEN KHYLMCERKA GMTKVDQLP