CLC10_HUMAN » C-type lectin domain family 10 member A

CLC10_HUMAN » C-type lectin domain family 10 member A
Magnify CLC10_HUMAN » C-type lectin domain family 10 member AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CLC10_HUMAN » C-type lectin domain family 10 member A » C-type lectin superfamily member 14;Macrophage lectin 2;
Hydrophobic Thickness 28.4 ± 2.6 Å
Tilt Angle 3 ± 1°
ΔGtransfer -31.5 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 39-61 (38-63)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 12-131, Hepatic lectin, N-terminal domain

AA: 198-306, PDBID: 1DV8, Subunit A, Seq Identity:73%, Lectin C-type domain

UniProt annotation for CLC10_HUMAN » C-type lectin domain family 10 member A
FUNCTION: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
UniProt features for CLC10_HUMAN » C-type lectin domain family 10 member A
CHAIN 1 316 C-type lectin domain family 10 member A.
DOMAIN 188 305 C-type lectin.
COILED 85 176 Potential.
MOTIF 5 8 Endocytosis signal (Potential).
DISULFID 181 192 By similarity.
DISULFID 209 304 By similarity.
DISULFID 282 296 By similarity.
Amino Acid Sequence for CLC10_HUMAN » C-type lectin domain family 10 member A
MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL LLVIICVVGF QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET IASLKAEVEG FKQERQAGVS ELQEHTTQKA HLGHCPHCPS VCVPVHSEML LRVQQLVQDL KKLTCQVATL NNNASTEGTC CPVNWVEHQD SCYWFSHSGM SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG LSDPEGAWKW VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY HWVCEAGLGQ TSQESH