CL12B_HUMAN » C-type lectin domain family 12 member B

CL12B_HUMAN » C-type lectin domain family 12 member B
Magnify CL12B_HUMAN » C-type lectin domain family 12 member BEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CL12B_HUMAN » C-type lectin domain family 12 member B » Macrophage antigen H;
Hydrophobic Thickness 42.0 ± 1.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -58.2 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 42-67 (37-70)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 36-157, PDBID: 1YPO, Subunit B, Seq Identity:22%, Ly49-like protein, N-terminal region

AA: 161-265, PDBID: 1HQ8, Subunit A, Seq Identity:37%, Lectin C-type domain

UniProt annotation for CL12B_HUMAN » C-type lectin domain family 12 member B
FUNCTION: Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

SUBUNIT: Homodimer. Interacts with PTPN6 and PTPN11.

TISSUE SPECIFICITY: Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for CL12B_HUMAN » C-type lectin domain family 12 member B
CHAIN 1 276 C-type lectin domain family 12 member B.
DOMAIN 150 264 C-type lectin.
MOTIF 5 10 ITIM motif.
DISULFID 172 263 By similarity.
DISULFID 242 255 By similarity.
Amino Acid Sequence for CL12B_HUMAN » C-type lectin domain family 12 member B
MSEEVTYATL TFQDSAGARN NRDGNNLRKR GHPAPSPIWR HAALGLVTLC LMLLIGLVTL GMMFLQISND INSDSEKLSQ LQKTIQQQQD NLSQQLGNSN NLSMEEEFLK SQISSVLKRQ EQMAIKLCQE LIIHTSDHRC NPCPKMWQWY QNSCYYFTTN EEKTWANSRK DCIDKNSTLV KIDSLEEKDF LMSQPLLMFS FFWLGLSWDS SGRSWFWEDG SVPSPSLFST KELDQINGSK GCAYFQKGNI YISRCSAEIF WICEKTAAPV KTEDLD