CL12A_HUMAN » C-type lectin domain family 12 member A

CL12A_HUMAN » C-type lectin domain family 12 member A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CL12A_HUMAN » C-type lectin domain family 12 member A » C-type lectin-like molecule 1;CLL-1; Dendritic cell-associated lectin 2;DCAL-2; Myeloid inhibitory C-type lectin-like receptor;MICL;
Hydrophobic Thickness 36.4 ± 1.6 Å
Tilt Angle 0 ± 2°
ΔGtransfer -49.3 kcal/mol
ΔGfold -27.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 51-79 (51-84)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 150-250, PDBID: 2C6U, Subunit A, Seq Identity:35%, Lectin C-type domain

UniProt annotation for CL12A_HUMAN » C-type lectin domain family 12 member A
FUNCTION: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

SUBUNIT: Interacts with PTPN6 and PTPN11.

TISSUE SPECIFICITY: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.

INDUCTION: Down-regulated in activated leukocytes recruited to a site of inflammation.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for CL12A_HUMAN » C-type lectin domain family 12 member A
CHAIN 1 265 C-type lectin domain family 12 member A.
DOMAIN 140 249 C-type lectin.
MOTIF 5 10 ITIM motif.
DISULFID 161 248 By similarity.
DISULFID 227 240 By similarity.
Amino Acid Sequence for CL12A_HUMAN » C-type lectin domain family 12 member A
MWIDFFTYSS MSEEVTYADL QFQNSSEMEK IPEIGKFGEK APPAPSHVWR PAALFLTLLC LLLLIGLGVL ASMFHVTLKI EMKKMNKLQN ISEELQRNIS LQLMSNMNIS NKIRNLSTTL QTIATKLCRE LYSKEQEHKC KPCPRRWIWH KDSCYFLSDD VQTWQESKMA CAAQNASLLK INNKNALEFI KSQSRSYDYW LGLSPEEDST RGMRVDNIIN SSAWVIRNAP DLNNMYCGYI NRLYVQYYHC TYKQRMICEK MANPVQLGST YFREA