CHL1_HUMAN » Neural cell adhesion molecule L1-like protein

CHL1_HUMAN » Neural cell adhesion molecule L1-like protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CHL1_HUMAN » Neural cell adhesion molecule L1-like protein » Close homolog of L1;
Hydrophobic Thickness 33.2 ± 4.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -52.5 kcal/mol
ΔGfold -21.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1081-1104 (1074-1107)
Pathways

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 35-127, PDBID: 2yd4, Subunit A, Seq Identity:34%, Immunoglobulin I-set domain

AA: 242-327, PDBID: 3p3y, Subunit A, Seq Identity:46%, Immunoglobulin I-set domain

AA: 331-418, PDBID: 3p3y, Subunit A, Seq Identity:36%, Immunoglobulin I-set domain

AA: 423-511, PDBID: 2v9q, Subunit A, Seq Identity:33%, Immunoglobulin I-set domain

AA: 514-608, Immunoglobulin domain

AA: 613-698, PDBID: 1uey, Subunit A, Seq Identity:45%, Fibronectin type III domain

AA: 713-796, PDBID: 1uey, Subunit A, Seq Identity:36%, Fibronectin type III domain

AA: 811-904, PDBID: 1uen, Subunit A, Seq Identity:36%, Fibronectin type III domain

AA: 917-1005, Fibronectin type III domain

AA: 1104-1191, Bravo-like intracellular region

UniProt annotation for CHL1_HUMAN » Neural cell adhesion molecule L1-like protein
FUNCTION: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).
SUBUNIT: May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Soluble forms produced by cleavage/shedding also exist (By similarity).
SUBCELLULAR LOCATION: Processed neural cell adhesion molecule L1- like protein: Secreted, extracellular space, extracellular matrix (By similarity).
TISSUE SPECIFICITY: Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.
DOMAIN: The FIG[AQ]Y motif seems to be an ankyrin recruitment region.
DOMAIN: The DGEA motif seems to be a recognition site for integrin.
UniProt features for CHL1_HUMAN » Neural cell adhesion molecule L1-like protein
SIGNAL 1 24 Potential.
CHAIN 25 1208 Neural cell adhesion molecule L1-like protein.
CHAIN 25 ? Processed neural cell adhesion molecule L1-like protein (Potential).
DOMAIN 35 124 Ig-like C2-type 1.
DOMAIN 128 223 Ig-like C2-type 2.
DOMAIN 235 328 Ig-like C2-type 3.
DOMAIN 331 417 Ig-like C2-type 4.
DOMAIN 423 510 Ig-like C2-type 5.
DOMAIN 515 607 Ig-like C2-type 6.
DOMAIN 612 704 Fibronectin type-III 1.
DOMAIN 711 804 Fibronectin type-III 2.
DOMAIN 809 911 Fibronectin type-III 3.
DOMAIN 916 1011 Fibronectin type-III 4.
MOTIF 555 558 DGEA.
MOTIF 1181 1185 FIG[AQ]Y.
SITE 753 754 Cleavage; by ADAM8 (By similarity).
SITE 1039 1040 Cleavage; by ADAM8 (By similarity).
DISULFID 57 109 By similarity.
DISULFID 153 204 By similarity.
DISULFID 262 310 By similarity.
DISULFID 352 401 By similarity.
DISULFID 445 494 By similarity.
DISULFID 536 591 By similarity.
Amino Acid Sequence for CHL1_HUMAN » Neural cell adhesion molecule L1-like protein
MEPLLLGRGL IVYLMFLLLK FSKAIEIPSS VQQVPTIIKQ SKVQVAFPFD EYFQIECEAK GNPEPTFSWT KDGNPFYFTD HRIIPSNNSG TFRIPNEGHI SHFQGKYRCF ASNKLGIAMS EEIEFIVPSV PKFPKEKIDP LEVEEGDPIV LPCNPPKGLP PLHIYWMNIE LEHIEQDERV YMSQKGDLYF ANVEEKDSRN DYCCFAAFPR LRTIVQKMPM KLTVNSSNSI KQRKPKLLLP PTESGSESSI TILKGEILLL ECFAEGLPTP QVDWNKIGGD LPKGRETKEN YGKTLKIENV SYQDKGNYRC TASNFLGTAT HDFHVIVEEP PRWTKKPQSA VYSTGSNGIL LCEAEGEPQP TIKWRVNGSP VDNHPFAGDV VFPREISFTN LQPNHTAVYQ CEASNVHGTI LANANIDVVD VRPLIQTKDG ENYATVVGYS AFLHCEFFAS PEAVVSWQKV EEVKPLEGRR YHIYENGTLQ INRTTEEDAG SYSCWVENAI GKTAVTANLD IRNATKLRVS PKNPRIPKLH MLELHCESKC DSHLKHSLKL SWSKDGEAFE INGTEDGRII IDGANLTISN VTLEDQGIYC CSAHTALDSA ADITQVTVLD VPDPPENLHL SERQNRSVRL TWEAGADHNS NISEYIVEFE GNKEEPGRWE ELTRVQGKKT TVILPLAPFV RYQFRVIAVN EVGRSQPSQP SDHHETPPAA PDRNPQNIRV QASQPKEMII KWEPLKSMEQ NGPGLEYRVT WKPQGAPVEW EEETVTNHTL RVMTPAVYAP YDVKVQAINQ LGSGPDPQSV TLYSGEDYPD TAPVIHGVDV INSTLVKVTW STVPKDRVHG RLKGYQINWW KTKSLLDGRT HPKEVNILRF SGQRNSGMVP SLDAFSEFHL TVLAYNSKGA GPESEPYIFQ TPEGVPEQPT FLKVIKVDKD TATLSWGLPK KLNGNLTGYL LQYQIINDTY EIGELNDINI TTPSKPSWHL SNLNATTKYK FYLRACTSQG CGKPITEESS TLGEGSKGIG KISGVNLTQK THPVEVFEPG AEHIVRLMTK NWGDNDSIFQ DVIETRGREY AGLYDDISTQ GWFIGLMCAI ALLTLLLLTV CFVKRNRGGK YSVKEKEDLH PDPEIQSVKD ETFGEYSDSD EKPLKGSLRS LNRDMQPTES ADSLVEYGEG DHGLFSEDGS FIGAYAGSKE KGSVESNGSS TATFPLRA