CEAM4_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 4

CEAM4_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CEAM4_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 4 » Carcinoembryonic antigen CGM7;Non-specific cross-reacting antigen W236;
Hydrophobic Thickness 36.0 ± 2.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -45.6 kcal/mol
ΔGfold -20.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 149-179 (149-179)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 39-141, PDBID: 1L6Z, Subunit A, Seq Identity:50%, Immunoglobulin V-set domain

UniProt annotation for CEAM4_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 4
FUNCTION: Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.

SUBUNIT: Interacts through its phosphorylated ITAM domain with the SH2 domain-containing cytoplasmic proteins involved in signaling processes during phagocytosis.

TISSUE SPECIFICITY: Granulocytes.

MISCELLANEOUS: To study the function of the orphan receptor CEACAM4 chimeric proteins containing the extracellular bacteria- binding domain of CEACAM3 and the transmembrane and cytoplasmic part of CEACAM4 has been used.

UniProt features for CEAM4_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 4
SIGNAL 1 35 Potential.
CHAIN 36 244 Carcinoembryonic antigen-related cell adhesion molecule 4.
DOMAIN 36 139 Ig-like V-type.
Amino Acid Sequence for CEAM4_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 4
MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD VLLLACNISE TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET VYPNGSLLFQ NITLEDAGSY TLRTINASYD SDQATGQLHV HQNNVPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLSRTG RASIQRDLRE QPPPASTPGH GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA DVVS