CEAM3_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 3

CEAM3_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CEAM3_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 3 » Carcinoembryonic antigen CGM1;
Hydrophobic Thickness 37.6 ± 3.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -48.3 kcal/mol
ΔGfold -20.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 152-179 (152-179)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CEAM1, Complex: CEAM3:CEAM1, PubMed

Domains

AA: 38-141, PDBID: 4WHC, Subunit B, Seq Identity:91%, Immunoglobulin V-set domain

UniProt annotation for CEAM3_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 3
FUNCTION: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

SUBUNIT: Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation.

TISSUE SPECIFICITY: CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.

DOMAIN: The cytosolic domain is involved in S100A9 interaction.

UniProt features for CEAM3_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 3
SIGNAL 1 34 By similarity.
CHAIN 35 252 Carcinoembryonic antigen-related cell adhesion molecule 3.
DOMAIN 35 142 Ig-like V-type.
Amino Acid Sequence for CEAM3_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 3
MGPPSASPHR ECIPWQGLLL TASLLNFWNP PTTAKLTIES MPLSVAEGKE VLLLVHNLPQ HLFGYSWYKG ERVDGNSLIV GYVIGTQQAT PGAAYSGRET IYTNASLLIQ NVTQNDIGFY TLQVIKSDLV NEEATGQFHV YQENAPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLAKTG RTSIQRDLKE QQPQALAPGR GPSHSSAFSM SPLSTAQAPL PNPRTAASIY EELLKHDTNI YCRMDHKAEV AS