CEAM1_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 1

CEAM1_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CEAM1_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 1 » Biliary glycoprotein 1;BGP-1;
Hydrophobic Thickness 36.0 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -45.2 kcal/mol
ΔGfold -26.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 427-455 (427-457)
Pathways none
PDB 2gk2 (A/B=34-141), 4qxw (A/B=35-141), 4qyc (A/B=38-141)
OPM none
Complexes

CEAM1:HAVR2_HUMAN

CEAM1:CEAM1_HUMAN

Interactions

CD209, Complex: CEAM1:CD209, PubMed

CEAM1, Complex: Homodimer of CEAM1, PDBID: 4QXW

CEAM3, Complex: CEAM3:CEAM1, PubMed

CLC4M, Complex: CEAM1:CLC4M, PubMed

EGFR, Complex: EGFR:CEAM1, PubMed

HAVR2, Complex: CEAM1:HAVR2, PDBID: 4QYC

INSR, Complex: INSR:CEAM1, PubMed

ITB3, Complex: ITB3:CEAM1, PubMed

Domains

AA: 38-141, PDBID: 2GK2, Subunit B, Seq Identity:100%, Immunoglobulin V-set domain

AA: 146-219, PDBID: 2DKS, Subunit A, Seq Identity:82%, Immunoglobulin domain

AA: 239-318, PDBID: 3BFO, Subunit D, Seq Identity:27%, Immunoglobulin domain

AA: 331-411, PDBID: 3WYR, Subunit B, Seq Identity:29%, Immunoglobulin domain

UniProt annotation for CEAM1_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 1
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Secreted.
SUBCELLULAR LOCATION: Isoform 3: Secreted.
SUBCELLULAR LOCATION: Isoform 4: Secreted.
SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 6: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 7: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of cell-cell contact.
UniProt features for CEAM1_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 1
SIGNAL 1 34
CHAIN 35 526 Carcinoembryonic antigen-related cell adhesion molecule 1.
DOMAIN 35 142 Ig-like V-type.
DOMAIN 145 232 Ig-like C2-type 1.
DOMAIN 237 317 Ig-like C2-type 2.
DOMAIN 323 413 Ig-like C2-type 3.
DISULFID 167 215 Probable.
DISULFID 259 299 Probable.
DISULFID 348 396 Probable.
Amino Acid Sequence for CEAM1_HUMAN » Carcinoembryonic antigen-related cell adhesion molecule 1
MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST NDTGISIRWF FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN PISKNQSDPI MLNVNYNALP QENGLSPGAI AGIVIGVVAL VALIAVALAC FLHFGKTGRA SDQRDLTEHK PSVSNHTQDH SNDPPNKMNE VTYSTLNFEA QQPTQPTSAS PSLTATEIIY SEVKKQ