CDON_HUMAN » Cell adhesion molecule-related/down-regulated by oncogenes

CDON_HUMAN » Cell adhesion molecule-related/down-regulated by oncogenes
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CDON_HUMAN » Cell adhesion molecule-related/down-regulated by oncogenes »
Hydrophobic Thickness 37.6 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -53.8 kcal/mol
ΔGfold -25.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 964-989 (962-993)
Pathways

Developmental Biology (Reactome)

PDB 3n1q (C/D/F=826-924), 3d1m (C/D=826-924), 3n1f (C/D=826-924)
OPM 3n1f
Complexes none
Interactions

BOC, Complex: CDON:BOC, PubMed

CAD15, Complex: CAD15:CDON, PubMed

CADH1, Complex: CADH1:CDON, PubMed

CADH2, Complex: CDON:CADH2, PubMed

Domains

AA: 28-101, PDBID: 2OM5, Subunit A, Seq Identity:33%, Immunoglobulin domain

AA: 221-294, PDBID: 3P3Y, Subunit A, Seq Identity:36%, Immunoglobulin domain

AA: 312-397, PDBID: 4U7M, Subunit A, Seq Identity:35%, Immunoglobulin I-set domain

AA: 404-504, PDBID: 1CS6, Subunit A, Seq Identity:29%, Immunoglobulin domain

AA: 578-667, PDBID: 2V5Y, Subunit A, Seq Identity:29%, Fibronectin type III domain

AA: 722-807, PDBID: 1X4Z, Subunit A, Seq Identity:66%, Fibronectin type III domain

AA: 826-916, PDBID: 3D1M, Subunit C, Seq Identity:100%, Fibronectin type III domain

UniProt annotation for CDON_HUMAN » Cell adhesion molecule-related/down-regulated by oncogenes
FUNCTION: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

SUBUNIT: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.

DISEASE: Holoprosencephaly 11 (HPE11) OMIM: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. mutations affecting the gene represented in this entry.

UniProt features for CDON_HUMAN » Cell adhesion molecule-related/down-regulated by oncogenes
SIGNAL 1 25 Potential.
CHAIN 26 1287 Cell adhesion molecule-related/down- regulated by oncogenes.
DOMAIN 29 114 Ig-like C2-type 1.
DOMAIN 120 204 Ig-like C2-type 2.
DOMAIN 225 303 Ig-like C2-type 3.
DOMAIN 310 396 Ig-like C2-type 4.
DOMAIN 405 516 Ig-like C2-type 5.
DOMAIN 577 673 Fibronectin type-III 1.
DOMAIN 721 813 Fibronectin type-III 2.
DOMAIN 826 923 Fibronectin type-III 3.
DISULFID 50 97 By similarity.
DISULFID 141 191 By similarity.
DISULFID 243 290 By similarity.
DISULFID 333 380 By similarity.
DISULFID 426 500 By similarity.
Amino Acid Sequence for CDON_HUMAN » Cell adhesion molecule-related/down-regulated by oncogenes
MHPDLGPLCT LLYVTLTILC SSVSSDLAPY FTSEPLSAVQ KLGGPVVLHC SAQPVTTRIS WLHNGKTLDG NLEHIKIHQG TLTILSLNSS LLGYYQCLAN NSIGAIVSGP ATVSVAVLGD FGSSTKHVIT AEEKSAGFIG CRVPESNPKA EVRYKIRGKW LEHSTENYLI LPSGNLQILN VSLEDKGSYK CAAYNPVTHQ LKVEPIGRKL LVSRPSSDDV HILHPTHSQA LAVLSRSPVT LECVVSGVPA PQVYWLKDGQ DIAPESNWRR LYSHLATDSV DPADSGNYSC MAGNKSGDVK YVTYMVNVLE HASISKGLQD QIVSLGATVH FTCDVHGNPA PNCTWFHNAQ PIHPSARHLT AGNGLKISGV TVEDVGMYQC VADNGIGFMH STGRLEIEND GGFKPVIITA PVSAKVADGD FVTLSCNASG LPVPVIRWYD SHGLITSHPS QVLRSKSRKS QLSRPEGLNL EPVYFVLSQA GASSLHIQAV TQEHAGKYIC EAANEHGTTQ AEASLMVVPF ETNTKAETVT LPDAAQNDDR SKRDGSETGL LSSFPVKVHP SAVESAPEKN ASGISVPDAP IILSPPQTHT PDTYNLVWRA GKDGGLPINA YFVKYRKLDD GVGMLGSWHT VRVPGSENEL HLAELEPSSL YEVLMVARSA AGEGQPAMLT FRTSKEKTAS SKNTQASSPP VGIPKYPVVS EAANNNFGVV LTDSSRHSGV PEAPDRPTIS TASETSVYVT WIPRANGGSP ITAFKVEYKR MRTSNWLVAA EDIPPSKLSV EVRSLEPGST YKFRVIAINH YGESFRSSAS RPYQVVGFPN RFSSRPITGP HIAYTEAVSD TQIMLKWTYI PSSNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGSKQWHM IGHLQPETSY DIKMQCFNEG GESEFSNVMI CETKVKRVPG ASEYPVKDLS TPPNSLGSGG NVGPATSPAR SSDMLYLIVG CVLGVMVLIL MVFIAMCLWK NRQQNTIQKY DPPGYLYQGS DMNGQMVDYT TLSGASQING NVHGGFLTNG GLSSGYSHLH HKVPNAVNGI VNGSLNGGLY SGHSNSLTRT HVDFEHPHHL VNGGGMYTAV PQIDPLECVN CRNCRNNNRC FTKTNSTFSS SPPPVVPVVA PYPQDGLEMK PLSHVKVPVC LTSAVPDCGQ LPEESVKDNV EPVPTQRTCC QDIVNDVSSD GSEDPAEFSR GQEGMINLRI PDHLQLAKSC VWEGDSCAHS ETENNIVSWN ALILPPVPEG CAEKTMWSPP GIPLDSPTEV LQQPRET