CDHR3_HUMAN » Cadherin-related family member 3

CDHR3_HUMAN » Cadherin-related family member 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CDHR3_HUMAN » Cadherin-related family member 3 » Cadherin-like protein 28;
Hydrophobic Thickness 31.2 ± 0.6 Å
Tilt Angle 0 ± 1°
ΔGtransfer -43.9 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 710-739 (707-740)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 141-227, PDBID: 3UBH, Subunit A, Seq Identity:28%, Cadherin domain

AA: 241-336, PDBID: 2A62, Subunit A, Seq Identity:31%, Cadherin domain

AA: 466-557, PDBID: 4ZI9, Subunit B, Seq Identity:32%, Cadherin domain

UniProt annotation for CDHR3_HUMAN » Cadherin-related family member 3
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

TISSUE SPECIFICITY: Expressed in bronchial epithelium from adults and in fetal lung tissue.

DISEASE: Note=Asthma susceptibility may be associated with variations affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age.

UniProt features for CDHR3_HUMAN » Cadherin-related family member 3
SIGNAL 1 19 Potential.
CHAIN 20 885 Cadherin-related family member 3.
DOMAIN 23 132 Cadherin 1.
DOMAIN 136 236 Cadherin 2.
DOMAIN 237 344 Cadherin 3.
DOMAIN 346 466 Cadherin 4.
DOMAIN 462 566 Cadherin 5.
DOMAIN 567 695 Cadherin 6.
Amino Acid Sequence for CDHR3_HUMAN » Cadherin-related family member 3
MQEAIILLAL LGAMSGGEAL HLILLPATGN VAENSPPGTS VHKFSVKLSA SLSPVIPGFP QIVNSNPLTE AFRVNWLSGT YFEVVTTGME QLDFETGPNI FDLQIYVKDE VGVTDLQVLT VQVTDVNEPP QFQGNLAEGL HLYIVERANP GFIYQVEAFD PEDTSRNIPL SYFLISPPKS FRMSANGTLF STTELDFEAG HRSFHLIVEV RDSGGLKAST ELQVNIVNLN DEVPRFTSPT RVYTVLEELS PGTIVANITA EDPDDEGFPS HLLYSITTVS KYFMINQLTG TIQVAQRIDR DAGELRQNPT ISLEVLVKDR PYGGQENRIQ ITFIVEDVND NPATCQKFTF SIMVPERTAK GTLLLDLNKF CFDDDSEAPN NRFNFTMPSG VGSGSRFLQD PAGSGKIVLI GDLDYENPSN LAAGNKYTVI IQVQDVAPPY YKNNVYVYIL TSPENEFPLI FDRPSYVFDV SERRPARTRV GQVRATDKDL PQSSLLYSIS TGGASLQYPN VFWINPKTGE LQLVTKVDCE TTPIYILRIQ ATNNEDTSSV TVTVNILEEN DEKPICTPNS YFLALPVDLK VGTNIQNFKL TCTDLDSSPR SFRYSIGPGN VNNHFTFSPN AGSNVTRLLL TSRFDYAGGF DKIWDYKLLV YVTDDNLMSD RKKAEALVET GTVTLSIKVI PHPTTIITTT PRPRVTYQVL RKNVYSPSAW YVPFVITLGS ILLLGLLVYL VVLLAKAIHR HCPCKTGKNK EPLTKKGETK TAERDVVVET IQMNTIFDGE AIDPVTGETY EFNSKTGARK WKDPLTQMPK WKESSHQGAA PRRVTAGEGM GSLRSANWEE DELSGKAWAE DAGLGSRNEG GKLGNPKNRN PAFMNRAYPK PHPGK